Evidence map›Paper›PMID 40594376›Full record

ArticleScientific reports2025

Osteoporosis in adjacent cervical segments exacerbates disc herniation.

Beiyang Wang, Yang Liu, Zhiqiang Wang, Chenguang Niu, Jian Tang, Lin Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beiyang WangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Yang LiuThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Zhiqiang WangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Chenguang NiuCollege of Mechanical and Vehicle Engineering, Taiy uan University of Technology, Taiyuan, People's Republic of China.
Jian TangCollege of Mechanical and Vehicle Engineering, Taiy uan University of Technology, Taiyuan, People's Republic of China.
Lin SunThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China. sunlin_9999@163.com.

Funding

shanxi provincial education department 2022YJJG121
6 · The paper itself

Abstract

Current studies into the relationship between osteoporosis and cervical disc herniation (CDH) remain inconclusive, primarily due to the scarcity of large-sample clinical follow-ups and biomechanical evidence. This retrospective, single-center study analyzed a consecutive series of 933 patients. We compared clinical parameters including age, gender, BMI, smoking history, alcohol consumption, steroid use history, thyroid dysfunction, diabetes history, and C5-C6 Hounsfield Unit (HU) values between groups with and without C5 disc herniation. Use multivariable-adjusted logistic regression to analyze the relationship between C5 and C6 vertebral body HU values and CDH. A finite element model was utilized to assess the impact of osteoporosis on cervical segments. In the Logistic regression analysis, after adjusting for confounding variables, the results showed that decreased HU values in the C5 (OR: 0.951, 95% CI: 0.911-0.992, P = 0.02) and C6 (OR: 0.923, 95% CI: 0.884-0.964, P < 0.001) segments were independent influencing factors for intervertebral disc herniation at the C5 level of the cervical spine. In addition, finite element analysis showed that articular cartilage stress decreased in the reduced bone density group, whereas disc stress and displacement increased. Osteoporosis of adjacent cervical segments increases the risk of disc herniation.

Indexed as

Cervical VertebraeIntervertebral Disc DisplacementOsteoporosisAdultAgedFemaleFinite Element AnalysisHumansMaleMiddle AgedRetrospective StudiesRisk FactorsBiomechanicsCervical spineClinical follow-upDisc herniationOsteoporosis

Identifiers

PMID40594376
PMCPMC12214985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.