Evidence map›Paper›PMID 40594341›Full record

ArticleScientific reports2025

MRI-derived articular cartilage strains predict patient-reported outcomes six months post anterior cruciate ligament reconstruction.

Emily Y Miller, Woowon Lee, Timothy Lowe, Hongtian Zhu, Pablo F Argote, Danielle Dresdner, James Kelly, Rachel M Frank, Eric McCarty, Jonathan Bravman and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Emily Y MillerBiomedical Engineering Program, University of Colorado Boulder, Boulder, CO, USA.
Woowon LeePaul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, USA.
Timothy LowePaul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, USA.
Hongtian ZhuPaul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, USA.
Pablo F ArgotePaul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, USA.
Danielle DresdnerBiomedical Engineering Program, University of Colorado Boulder, Boulder, CO, USA.
James KellyBiomedical Engineering Program, University of Colorado Boulder, Boulder, CO, USA.
Rachel M FrankOrthopaedic Sports Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Eric McCartyOrthopaedic Sports Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jonathan BravmanOrthopaedic Sports Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Daniel StokesOrthopaedic Sports Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Nancy C EmeryDepartment of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA.
Corey P NeuBiomedical Engineering Program, University of Colorado Boulder, Boulder, CO, USA. cpneu@colorado.edu.

Funding

Probing Osteoarthritis Pathogenesis by Noninvasive Imaging of Cartilage StrainR01AR063712 · NIAMS · UNIVERSITY OF COLORADO · PI NEU, COREY P · 2013 to 2023
$4.7M
NIAMS NIH HHS R01 AR063712NIH HHS R01 AR063712
6 · The paper itself

Abstract

Anterior cruciate ligament (ACL) injuries lead to an increased risk of osteoarthritis (OA). However, efforts to diagnose OA before irreversible changes to the joint occur remain limited. In this work, we utilized both quantitative MRI (qMRI) and displacements under applied loading MRI (dualMRI) to determine if relaxometry measures derived from qMRI and strains derived from dualMRI correlate with patient-reported outcomes at six months post unilateral ACL reconstruction. Quantitative MRI (T2, T2*, T1ρ) measurements and dualMRI strains (transverse, axial, and shear strains) were quantified in the medial articular tibiofemoral cartilage of 35 participants at six-months post unilateral ACL reconstruction. The relationships between patient-reported outcome scores and all MRI metrics were quantified using general linear mixed-effects models and a combined best-fit multicontrast MRI model was then developed. Higher femoral shear and transverse strains were significantly correlated with worse patient-reported outcomes. No relaxometry measures were correlated with patient-reported outcome scores. We identified the best-fit model for predicting patient-reported outcome score using multiple MRI measures and patient-specific information. The best-fit model significantly predicted patient-reported outcome score (p < 0.001, R

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionCartilage, ArticularMagnetic Resonance ImagingPatient Reported Outcome MeasuresAdultFemaleHumansMaleMiddle AgedOsteoarthritis, KneeYoung AdultFunctional biomechanical imagingKnee joint degenerationMagnetic resonance imagingMulticontrast and multiparametricOsteoarthritis

Identifiers

PMID40594341
PMCPMC12214938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.