Evidence map›Paper›PMID 40594314›Full record

ArticleScientific reports2025

The effect of pre-transplant dialysis duration on the relationship between delayed graft function and recipient death.

Rui-Yu Wang, Dan Jia, Shuan-Hong Wang, Shang-Guo Wang, Bin Liu, Lei Yang, Wen-Qiang Zhang, Hao Wu, Bao-Shan Gao

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Rui-Yu WangUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Dan JiaUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Shuan-Hong WangPre-hospital Emergency Center, Tongliao City Hospital, No.668, Horchin Street, Tongliao, 028000, Inner Mongolia, China.
Shang-Guo WangUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Bin LiuUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Lei YangUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Wen-Qiang ZhangUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Hao WuUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China.
Bao-Shan GaoUrology Center, The First Hospital of Jilin University, No.71, Xinmin Street, Changchun, 130021, Jilin, China. gaobs@jlu.edu.cn.

Funding

Science and Technology Plan Project of Jilin Province 20210101440JC
6 · The paper itself

Abstract

The aim of this study was to evaluate the effect of delayed graft function (DGF) on recipient death after kidney transplant from donors after brain death (DBD) stratified by pre-transplant dialysis duration. Using a retrospective database, this study collected clinical data from 1,311 patients who underwent DBD kidney transplantation. Univariate and multivariate Cox regression analyses were performed to assess the relationship between the DGF and recipient death. We applied a competing risk analysis model to explore the risk factors associated with DGF. The interaction between DGF and pre-transplant dialysis duration on recipient death was then further determined and analysed in subgroups. In addition, an individualised prediction model for recipient death was developed in the group with an extended pre-transplant dialysis duration. Overall, 53 patients (4.0%) died after kidney transplantation. DGF was independently associated with recipient death (HR: 2.672, 95% CI: 1.441-4.954, P = 0.002). A significant interaction was found between DGF and pre-transplant dialysis duration on recipient death (P = 0.037). In the extended pre-transplant dialysis duration (> 24.7 months), recipient age (HR: 1.059, 95% CI: 1.019-1.102, P = 0.004), donor age (HR: 1.050, 95% CI: 1.005-1.096, P = 0.027), and DGF level (HR: 4.311, 95% CI: 2.003-9.279, P < 0.001) were independent risk factors for recipient death. Furthermore, in the group of patients with extended pre-transplant dialysis duration, a predictive model based on DGF, recipient age, and donor age showed good predictive accuracy, calibration, and clinical utility. DGF was associated with recipient death within 3 years after DBD kidney transplantation only in patients with an extended pre-transplant dialysis duration, suggesting that pre-transplant dialysis duration is associated with whether DGF is an independent risk factor for recipient death.

Indexed as

Delayed Graft FunctionKidney TransplantationRenal DialysisAdultBrain DeathFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTime FactorsTissue DonorsDGFKidney transplantPrediction modelPre-transplant dialysis durationRecipient death

Identifiers

PMID40594314
PMCPMC12215338

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