Serum estradiol on the day of final oocyte maturation and outcome of assisted reproduction in women with thyroid autoimmunity.

Sanja Medenica, Durairaj Arjunan, Eliana Garalejic, Pinaki Dutta, Milos Zarkovic

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Sanja MedenicaDepartment of Endocrinology, Internal Medicine Clinic, School of Medicine, Clinical Center of Montenegro, University of Montenegro, Podgorica, Montenegro.

Durairaj ArjunanDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Nehru Hospital Extension PGIMER, Chandigarh, India.

Eliana GaralejicIn Vitro Fertilisation Department, Clinic for Gynecology and Obstetrics "Narodni front", Belgrade, Serbia.

Pinaki DuttaDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Nehru Hospital Extension PGIMER, Chandigarh, India. drpinakidutta12@gmail.com.ORCID https://orcid.org/0000-0001-5415-1611

Milos ZarkovicSchool of Medicine, University of Belgrade, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This retrospective study included 52 euthyroid women (with TAI, n = 26; without TAI, n = 26) undergoing ART. Based on E2 levels on the day of final oocyte maturation (DFOM) they were subdivided into Group A1 (TAI, E2 < 7,000 pmol/l), Group A2 (TAI, E2 > 7,000 pmol/l), Group B1 (no TAI, E2 < 7,000 pmol/l), and Group B2 (no TAI, E2 > 7,000 pmol/l), to compare outcomes related to oocytes, embryos, and pregnancy. Group A2 had significantly more retrieved oocytes than A1, but no difference in good-quality oocytes, retrieved embryos, top-quality embryos, or pregnancy outcomes. Group B2 had a significantly higher number of retrieved oocytes [11 (8.25, 15.5) vs. 6.50 (3.75, 8.25), p = 0.001], good-quality oocytes [8.5 (6.25, 10.5) vs. 5 (1.75, 6), p = 0.001], retrieved embryos [5 (4, 8.5) vs. 3.75 (1.75, 4.25), p = 0.011] and top-quality embryos [4.5 (3, 6) vs. 3 (1, 4), p = 0.023], compared to Group B1, respectively. The positive correlation between high E2 levels and ART outcomes persisted after adjusting for potential confounders. Higher E2 levels on DFOM are linked to better oocyte and embryo outcomes, especially in patients without TAI, but don't correlate with improved pregnancy outcomes.

Indexed as

AutoimmunityEstradiolOocytesReproductive Techniques, AssistedAdultFemaleHumansOocyte RetrievalPregnancyPregnancy OutcomePregnancy RateRetrospective StudiesEstradiolAssisted reproductive technologyEstradiolEstradiol level and ARTPregnancy outcomes in ARTSerum estradiol levels on the day of final oocyte maturationThyroid autoimmunityThyroid autoimmunity and ART

Identifiers

PMID40594295

DOI10.1038/s41598-025-04991-5

PMCPMC12216336

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.