Evidence map›Paper›PMID 40594275›Full record

ArticleScientific reports2025

The association between frailty status and cognitive function in patients with cardiovascular diseases: a nationwide cohort study.

Wanchunxue Jiang, Meng Wei, Qianhui Wang, Pengcheng Fan, Zukela Tuerhong, Yanmei Lu, Baopeng Tang, Xianhui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wanchunxue Jiang *Department of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Meng Wei *Department of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Qianhui WangDepartment of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Pengcheng FanDepartment of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Zukela TuerhongDepartment of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Yanmei LuDepartment of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China.
Baopeng Tang *Department of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. tangbaopeng1111@163.com.
Xianhui Zhou *Department of Cardiac Pacing and Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. zhouxhuiyf@163.com.

Funding

the Key Project of the Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01D15the Xinjiang Uygur Autonomous Region Science and Technology Innovation Leading Talent Program 2023TSYCLJ0036the Youth Scientific Research Voyage 2023YFY-QKMS-09
6 · The paper itself

Abstract

In individuals with cardiovascular disease, the commonly observed comorbid conditions are frailty and cognitive impairment. However, currently, the impact of cognitive function on frailty and the dynamic interplay between both in patients with cardiovascular disease are ambiguous. This cohort study explored the association between frailty and cognitive function in Chinese adults with cardiovascular conditions, specifically focusing on those who were middle-aged or older. This study aims to elucidate the temporal interactions and potential causal relationships between these two variables by incorporating a cross-lagged panel model analysis. Cognitive function was observed to significantly predict cognitive function at the subsequent time point using autoregressive analysis within the cross-lagged model (β = 1.105, P < 0.001). Significant temporal variations were identified in the impact of early stage of frailty status on cognitive function in the bidirectional interaction assessment (β = 0.293, P = 0.006). However, a shift was noted in later stages, with a significantly negative effect of the frailty status on the cognitive function from the third to the fourth wave (β = -1.102, P < 0.001). Both frailty status and cognitive function exhibit a certain degree of temporal stability and a significant bidirectional association.

Indexed as

Cardiovascular DiseasesCognitionCognitive DysfunctionFrailtyAgedAged, 80 and overChinaCohort StudiesFemaleHumansMaleMiddle AgedCardiovascular diseaseCognitive functionCross-lag modelFrailty

Identifiers

PMID40594275
PMCPMC12214522

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.