Trial reportScientific reports2025
Effect of hyperbaric oxygen therapy on postoperative muscle damage and inflammation following total knee arthroplasty: a randomized controlled trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association Between Intraoperative Arterial Oxygen Tension and Postoperative Opioid Consumption: A Large-Scale Cohort Study Using Overlap Weighting Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- Effectiveness of Hyperbaric Oxygen Therapy for Musculoskeletal Pain Syndromes: A Systematic Review.Muscles (Basel, Switzerland) · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This study aims to investigate the effect of hyperbaric oxygen therapy (HBOT) on muscle damage and inflammatory responses after total knee arthroplasty (TKA). This study selected 80 patients requiring TKA for primary knee osteoarthritis from July 2023 to December 2023 and equally randomized them into two groups-the HBOT and control groups-with 40 patients in each group. The HBOT group received standard treatment supplemented with HBOT, whereas the control group received normobaric oxygen therapy. Muscle damage markers, including glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), lactate dehydrogenase (LDH), and myoglobin (Mb), as well as inflammatory responses were compared preoperatively and 1, 3, and 14 days postoperatively. Additionally, limb circumference, quadriceps muscle strength, and the range of motion (ROM) of the affected limb were measured preoperatively and postoperatively. Any adverse events were documented. The HBOT group demonstrated a significant reduction in muscle damage 3 days post-TKA compared with the control group. A statistically significant acceleration in the recovery of quadriceps muscle strength and a decrease in the ratio of postoperative limb swelling accompanied this reduction. The HBOT group demonstrated a statistically significant alleviation of inflammatory responses 3 days postoperatively compared to the control group. Additionally, the visual analog scale (VAS) scores decreased for both rest and motion 2 and 3 days postoperatively, indicating an improved early ROM. Notably, no significant differences in postoperative adverse events were found between the two groups. The use of HBOT in the postoperative care of patients undergoing TKA has proven to be effective in mitigating muscle damage and alleviating inflammatory responses.Trial registration: Chinese Clinical Trial Registry (ChiCTR2300072685). Registered 21/6/2023, ULR of trial registry: https://www.chictr.org.cn/bin/project/edit?%20pid=198904 .
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