Evidence map›Paper›PMID 40594196›Full record

ArticleScientific reports2025

Automated gait analysis indicates efficacy of T-type calcium channel inhibition for mitigation of disrupted calcium signalling in an SCA5 mouse model.

Daumante Suminaite, Nurul Fatihah Talib, Sophie Jane Pettegree, Han Chew Gaelan Tan, Yvonne Louise Odey, Emma Margaret Perkins, Alastair Robert Lyndon, Paul Andrew Skehel, Mandy Jackson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The influence of trait anxiety on performance in the CatWalk test.Frontiers in behavioral neuroscience · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daumante SuminaiteThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Nurul Fatihah TalibThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Sophie Jane PettegreeThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Han Chew Gaelan TanThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Yvonne Louise OdeyThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Emma Margaret PerkinsThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Alastair Robert LyndonInstitute of Life and Earth Sciences, Heriot-Watt University, John Muir Building, Riccarton, Edinburgh, EH14 4AS, UK.
Paul Andrew SkehelThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK.
Mandy JacksonThe Centre for Discovery Brain Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK. Mandy.Jackson@ed.ac.uk.

Funding

Wellcome TrustWellcome Trust 093077
6 · The paper itself

Abstract

Spinocerebellar ataxias (SCAs) are dominantly inherited progressive neurodegenerative disorders which to date have no effective treatment. SCA5 arises from mutations in the β-III spectrin gene (SPTBN2) with mice lacking β-III spectrin function (β-III

Indexed as

Calcium Channel BlockersCalcium Channels, T-TypeCalcium SignalingGaitSpinocerebellar AtaxiasAnimalsCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Disease Models, AnimalMibefradilMiceMice, KnockoutPhosphorylationPurkinje CellsSpectrinCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium Channel BlockersCalcium Channels, T-TypeMibefradilSpectrin

Identifiers

PMID40594196
PMCPMC12216376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.