Evidence map›Paper›PMID 40594193›Full record

ArticleScientific reports2025

Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway.

Chenchun Ding, Renjie Zuo, Quan Liao, Zhenzhen Guo, Junjie He, Ziwei Ye, Guoyan Liu

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Chenchun DingDepartment of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
Renjie ZuoDepartment of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
Quan LiaoDepartment of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
Zhenzhen GuoSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, Fujian, China.
Junjie HeDepartment of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
Ziwei YeSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, Fujian, China.
Guoyan LiuDepartment of Gastrointestinal Surgery, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China. liuguoyan@xmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is an age-related disease with an unclear pathogenesis. The senescence and insufficient regeneration of alveolar epithelial cells are significant factors in the development and progression of IPF. Currently, effective treatment methods are lacking. The aim of this study is to explore the mechanism of action of uridine in delaying the aging of AECs and intervening in IPF. In vitro, Western blot and qRT-PCR analyzed uridine's effects on bleomycin-induced senescence, EMT, cell viability, and cell cycle. In vivo, uridine's impact on lung aging and fibrosis in BLM-induced mice was assessed by weight, staining, Ashcroft scoring, and Western blot. Uridine reduced senescence markers in A549 cells, suppressed epithelial-mesenchymal transition, improved antioxidant capacity, and delayed pulmonary fibrosis and lung aging in mice. The effects of uridine were mediated through the NRF2 signaling pathway, which regulates antioxidant defense and autophagy. Uridine enhanced autophagic degradation of Keap1, possibly through p62/SQSTM1-mediated autophagy. These findings suggest that uridine inhibits AEC senescence via the NRF2 pathway, mitigating IPF progression and offering a potential strategy for treating age-related pulmonary fibrosis by targeting oxidative stress.

Indexed as

Alveolar Epithelial CellsCellular SenescenceIdiopathic Pulmonary FibrosisKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Signal TransductionUridineA549 CellsAnimalsAutophagyBleomycinDisease Models, AnimalEpithelial-Mesenchymal TransitionHumansMaleMiceBleomycinKEAP1 protein, humanKeap1 protein, mouseKelch-Like ECH-Associated Protein 1NFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2UridineIdiopathic pulmonary fibrosis (IPF)Nrf2 signaling pathwayp62/SQSTM1Uridine; Senescence

Identifiers

PMID40594193
PMCPMC12214622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.