Evidence map›Paper›PMID 40594151›Full record

ArticleScientific reports2025

Synthesis and evaluation of thiazolyl coumarin drug conjugates as carbonic anhydrase isozyme inhibitors by using integrated invitro and insilico approaches.

Atteeque Ahmed, Romaisa Kanwal, Pervaiz Ali Channar, Mohammad Y Alshahrani, Aamer Saeed, Syeda Abida Ejaz, Hafiz Muhammad Attaullah, Rifhat Bibi, Chen Li

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Atteeque AhmedDepartment of Chemistry, Quaid-i-Azam University, Islamabad, 45321, Pakistan. aahmed@chem.qau.edu.pk.
Romaisa KanwalDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Pervaiz Ali ChannarDepartment of Basic Science & humanities, Dawood University of Engineering & Technology, Karachi, 74800, Pakistan.
Mohammad Y AlshahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O.Box 61413, Abha, 9088, Saudi Arabia.
Aamer SaeedDepartment of Chemistry, Quaid-i-Azam University, Islamabad, 45321, Pakistan. aamersaeed@yahoo.com.
Syeda Abida EjazDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan. abida.ejaz@iub.edu.pk.ORCID http://orcid.org/0000-0002-8516-7234
Hafiz Muhammad AttaullahDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Rifhat BibiDepartment of Chemistry, Quaid-i-Azam University, Islamabad, 45321, Pakistan.
Chen LiDepartment of Pharmacy, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new series of thiazolyl-coumarin-drug conjugates were synthesized through the reaction of 3-bromoacetylcoumarin and N-substituted and N, N-di-substituted thioureas. The synthesized compounds were characterized by

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesCoumarinsThiazolesHumansIsoenzymesMolecular Docking SimulationStructure-Activity RelationshipCarbonic Anhydrase InhibitorsCarbonic AnhydrasescoumarinCoumarinsIsoenzymesThiazolesCoumarinsSubstituted thioureasThiazolyl-coumarin drugs

Identifiers

PMID40594151
PMCPMC12219748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.