Evidence map›Paper›PMID 40594088›Full record

ArticleScientific reports2025

Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling.

Mücahit Varlı, Kyungha Lee, Tran The Bach, Tran Duc Binh, Hangun Kim, Kyo Bin Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mücahit Varlı *College of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Korea.
Kyungha Lee *College of Pharmacy and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University, 100 Cheongpa-ro 47 gil, Yongsan-gu, Seoul, 04310, Korea.
Tran The BachInstitute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Tran Duc BinhInstitute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Ha Noi, Vietnam.
Hangun KimCollege of Pharmacy, Sunchon National University, 255 Jungang-ro, Suncheon-si, Jeollanam-do, 57922, Korea. hangunkim@sunchon.ac.kr.
Kyo Bin KangCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University, 100 Cheongpa-ro 47 gil, Yongsan-gu, Seoul, 04310, Korea. kbkang@sookmyung.ac.kr.

Funding

Ministry of Science and Technology ĐTĐL.CN-72/22National Research Foundation of Korea NRF-2021K1A3A1A21038059National Research Foundation of Korea RS-2024-00413760
6 · The paper itself

Abstract

Epithelial-mesenchymal transition (EMT) is a critical process in cancer cell motility and metastasis. Monoterpene indole alkaloids (MIAs) have been widely investigated for biological activities, but rarely been explored for cell motility inhibition. This study aimed to discover natural products, especially focusing on MIAs, that inhibit EMT in cancer cells, based on our screening using multiple plant extracts. We found that an extract of the aerial parts of Uncaria scandens (Sm.) Wall. (Rubiaceae) decreased cancer cell motility. Targeted isolation exhibited eight MIAs. Among them, strictosamide and mitraphylline suppressed the invasion and migration of the cells. The alteration of the mRNA expression of the EMT effectors and transcription factors suggested that the EMT signaling pathway is related to the suppression of cancer cell motility by both compounds. RT-PCR gene array suggested inhibition of integrin α4 signaling as a potential mechanism of the EMT inhibition, which was supported by the quantitative analysis of the mRNA expressions of the related genes. Together, present study is the first report highlighting the cell motility-suppressive effects of strictosamide and mitraphylline. Our results suggested the potential applicability of strictosamide and mitraphylline for the prevention of metastasis.

Indexed as

Cell MovementEpithelial-Mesenchymal TransitionIndole AlkaloidsSignal TransductionCell Line, TumorGene Expression Regulation, NeoplasticHumansPlant ExtractsIndole AlkaloidsPlant ExtractsBioactivity-guided fractionationIntegrin Α4β1 agonistMetastasis suppressorSpirocylic oxindole alkaloidVallesiachotaman-type alkaloid

Identifiers

PMID40594088
PMCPMC12217235

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.