ArticleNPJ Parkinson's disease2025
EEG alpha peak frequency: cognitive impairment severity marker in isolated REM sleep behavior disorder.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Redefinition of EEG frequency bands: a fractal model inspired by Blagg's Titius-Bode law.Frontiers in systems neuroscience · 2026Article
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8 authors.
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Abstract
Isolated REM sleep behavior disorder (iRBD) is a prodrome of α-synucleinopathies like Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The best marker for prediction of lead time to phenoconversion is reduced striatal dopamine transporter (DaT)-binding, unavailable for most patients. This study investigated EEG alpha peak frequency (APF) slowing - an established marker of cognitive deterioration - as a severity marker in iRBD patients. In 320 patients clinically suspected of RBD 3-night-polysomnography was performed. After exclusion of 131 patients, mainly due to psychotropic medication, three groups were studied: Non-Syn - motor behavior unrelated to RBD (n = 34); iRBD (n = 122); RBD converted to overt α-synucleinopathies (PD = 19; DLB = 14). Data show in patients with iRBD significant correlations between APF, DaT-binding ratios and cognition. The strong correlation of APF < 8 Hz with caudate DaT-binding (r = 0.50-0.65) suggests, APF could be an easy-to-use severity marker for counseling patients on lead time until possible conversion to overt α-synucleinopathy especially in DLB.
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