ArticleNature communications2025
Lactate promotes invasive Klebsiella pneumoniae liver abscess syndrome by increasing capsular polysaccharide biosynthesis via the PTS-CRP axis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for invasiveFrontiers in cellular and infection microbiology · 2026Pooled it
- Article
- Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sugar import suppresses Klebsiella pneumoniae Mucoidy in a cAMP-CRP-dependent manner.Nature communications · 2026Article
- Molecular and mechanistic insights into the gut-liver axis inInfection and immunity · 2026Review
- Global Control of Phosphotransferase System-Mediated Carbon Metabolism by CRP Is Associated with Metabolic Homeostasis and Virulence inMicroorganisms · 2026Article
- High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infection.Nature communications · 2026Article
- Interventional treatment of a bacterial embolus in the retrohepatic inferior vena cava secondary to invasive Klebsiella pneumoniae liver abscess syndrome: a case report and literature review.Frontiers in cardiovascular medicine · 2026Article
- How do immunometabolites shape bacterial infections?PLoS biology · 2026Article
- Sugar Import SuppressesbioRxiv : the preprint server for biology · 2025Article
- Epidemiological and characteristic differences of hypervirulent and classicalFrontiers in cellular and infection microbiology · 2025Article
- Development and validation of a prediction model for invasive syndrome in liver abscess patients based on LASSO regression: a multi-center retrospective cohort study in China.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The global incidence of invasive Klebsiella pneumoniae liver abscess syndrome (IKPLAS) increases, yet its underlying molecular mechanisms remain elusive, hindering the development of effective therapeutic strategies. In this study, we analyze bacterial molecular profiles and clinical data from patients with KPLA and IKPLAS, and find no significant difference in the molecular characteristics of K. pneumoniae between the two groups, however, we identify elevated blood lactate levels as an independent predictor of IKPLAS. Further investigation reveals that lactate enhances K. pneumoniae virulence by promoting capsular polysaccharide (CPS) biosynthesis. Mechanistically, lactate reduces cyclic adenosine monophosphate (cAMP) levels by downregulating the expression of mannose-specific phosphotransferase system (man-PTS) enzyme IIA-D genes (gfrA, gfrB, gfrC and gfrD). This reduction in cAMP levels enhances CPS biosynthesis by decreasing its binding to the cAMP receptor protein (CRP). Our results highlight lactate's role in enhancing the virulence of K. pneumoniae via the PTS-CRP axis, offering insights into the pathogenesis of IKPLAS.
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