Evidence map›Paper›PMID 40593804›Full record

ArticleScientific reports2025

Genome-wide association analysis and gene mining of flavonoids in Xanthoceras sorbifolia.

Yuxue Huo, Lei Wang, Lu Lu, Dan Wu, Li Liu, Xiaoman Xie, Yongjun Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Study on differences in flavonoid synthesis inFrontiers in plant science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuxue HuoKey Laboratory of National Forestry and Grassland Administration on Conservation and Utilization of Warm Temperate Zone Forest and Grass Germplasm Resources, Shandong Provincial Center of Forest and Grass Germplasm Resources, Jinan, 250102, China.
Lei WangKey Laboratory of National Forestry and Grassland Administration on Conservation and Utilization of Warm Temperate Zone Forest and Grass Germplasm Resources, Shandong Provincial Center of Forest and Grass Germplasm Resources, Jinan, 250102, China.
Lu LuKey Laboratory of National Forestry and Grassland Administration on Conservation and Utilization of Warm Temperate Zone Forest and Grass Germplasm Resources, Shandong Provincial Center of Forest and Grass Germplasm Resources, Jinan, 250102, China.
Dan WuKey Laboratory of National Forestry and Grassland Administration on Conservation and Utilization of Warm Temperate Zone Forest and Grass Germplasm Resources, Shandong Provincial Center of Forest and Grass Germplasm Resources, Jinan, 250102, China.
Li LiuKey Laboratory of National Forestry and Grassland Administration on Conservation and Utilization of Warm Temperate Zone Forest and Grass Germplasm Resources, Shandong Provincial Center of Forest and Grass Germplasm Resources, Jinan, 250102, China.
Xiaoman XieKey Laboratory of National Forestry and Grassland Administration on Conservation and Utilization of Warm Temperate Zone Forest and Grass Germplasm Resources, Shandong Provincial Center of Forest and Grass Germplasm Resources, Jinan, 250102, China. xxm529@126.com.
Yongjun ZhaoKey Laboratory of National Forestry and Grassland Administration on Conservation and Utilization of Warm Temperate Zone Forest and Grass Germplasm Resources, Shandong Provincial Center of Forest and Grass Germplasm Resources, Jinan, 250102, China. 13305317857@163.com.

Funding

Shandong Provincial Key Research and Development Program (Agricultural Seed Project) 2020LZGC0904
6 · The paper itself

Abstract

Xanthoceras sorbifolia is a unique woody oilseed tree in China, and its leaves are rich in flavonoids, which are involved in plant growth, development and defense. However, the mining of flavonoid synthesis-related genes in Xanthoceras sorbifolia leaves is lacking. In this study, 226 leaves of Xanthoceras sorbifolia from eight provinces in the key distribution areas were measured for flavonoid content, and the differences in flavonoid content of Xanthoceras sorbifolia were analysed to screen out excellent seed sources and six excellent single plants with higher flavonoid content. Genome-wide association analysis (GWAS) was used to identify genes controlling the synthesis of flavonoids, and 62 significant Single nucleotide polymorphism (SNP) sites were identified, which were closely associated with 8 traits, and a total of 11 genes coding for proteins. We found that these genes mainly encode proteins such as WPP domain-associated protein (WAP) (Fragment), Protein pleiotropic regulatory locus 1 (PRL1) and Phosphomevalonate kinase, peroxisomal (PMK), etc. We found that these proteins may directly or indirectly affect the synthesis of flavonoids, which will provide a data base for molecular breeding and genetic improvement of Xanthoceras sorbifolia.

Indexed as

FlavonoidsGenome-Wide Association StudySapindaceaePlant LeavesPlant ProteinsPolymorphism, Single NucleotideFlavonoidsPlant ProteinsFlavonoidsGWASSNP screeningWhole genome resequencingXanthoceras sorbifolia

Identifiers

PMID40593804
PMCPMC12216634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.