Evidence map›Paper›PMID 40593778›Full record

ArticleNature communications2025

Natural variation in histone demethylase GmLDL2 confers flowering time divergence for geographical expansion in soybean.

Mengshi Liu, Yuan Fang, Jiacan Jiang, Huaizhen Chen, Bing Yang, Xiaomin Xu, Guoqiang Liu, Chen Ling, Zhicheng Dong, Cunyi Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengshi Liu *Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Yuan Fang *Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Jiacan Jiang *Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Huaizhen ChenGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Bing YangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.ORCID http://orcid.org/0000-0002-1424-1222
Xiaomin XuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Guoqiang LiuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Chen LingGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Zhicheng DongGuangzhou Key Laboratory of Crop Gene Editing, Innovative Center of Molecular Genetics and Evolution, School of Life Sciences, Guangzhou University, Guangzhou, China.ORCID http://orcid.org/0000-0003-2909-5720
Cunyi YangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Plant Molecular Breeding, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong, China. ycy@scau.edu.cn.ORCID http://orcid.org/0000-0001-8316-5844
Yingxiang WangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Life Sciences, South China Agricultural University, Guangzhou, 510642, Guangdong, China. yxwang@scau.edu.cn.ORCID http://orcid.org/0000-0001-6085-5615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flowering at the appropriate time is one of the critical traits to determine regional adaptation and yield of soybeans. Although several genes in regulating flowering time have been identified in soybeans, the epigenetic regulators are still largely unknown. Here, we identify an early flowering mutant (ef1) and clone the causal gene as lysine-specific demethylase like 2 (GmLDL2). Enzymatic activity assay shows that GmLDL2 has demethylase activity towards H3K4me1 and H3K4me2. Integrative ChIP-seq and RNA-seq analyses demonstrate that GmLDL2 directly inhibits the expression of GmFER, an ortholog of Arabidopsis FERONIA. Genetic analysis reveals that GmLDL2 regulates soybean flowering in a GmFER-dependent manner. Interestingly, both GmLDL2

Indexed as

FlowersGlycine maxHistone DemethylasesPlant ProteinsGene Expression Regulation, PlantGenetic VariationHistonesMutationHistone DemethylasesHistonesPlant Proteins

Identifiers

PMID40593778
PMCPMC12215685

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.