Evidence map›Paper›PMID 40593737›Full record

SynthesisNature communications2025

Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants.

Franz Förster, David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel and 13 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Franz FörsterInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Germany. franz.foerster@imise.uni-leipzig.de.ORCID http://orcid.org/0000-0002-2246-6843
David EmmertInstitute for Biomedicine, Eurac Research, Bolzano, Italy.ORCID http://orcid.org/0000-0001-8149-1072
Katrin HornInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0002-5307-6936
Janne PottInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Germany.
Johannes FrasnelliInstitute for Biomedicine, Eurac Research, Bolzano, Italy.
Mohammed Aslam ImtiazGerman Centre for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany.ORCID http://orcid.org/0000-0003-2762-3227
Konstantinos MelasGerman Centre for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany.ORCID http://orcid.org/0009-0000-5206-5322
Valentina TaleviGerman Centre for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany.
Honglei ChenDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0002-7247-282X
Michele FilosiInstitute for Biomedicine, Eurac Research, Bolzano, Italy.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Martin GögeleInstitute for Biomedicine, Eurac Research, Bolzano, Italy.ORCID http://orcid.org/0000-0003-4785-4348
Markus LöfflerInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Germany.
Thomas H MosleyThe Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
Cristian PattaroInstitute for Biomedicine, Eurac Research, Bolzano, Italy.
Peter PramstallerInstitute for Biomedicine, Eurac Research, Bolzano, Italy.ORCID http://orcid.org/0000-0002-9831-8302
Srishti ShresthaThe Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
N Ahmad AzizGerman Centre for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany.ORCID http://orcid.org/0000-0001-6184-458X
Monique M B BretelerGerman Centre for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany.ORCID http://orcid.org/0000-0002-0626-9305
Kerstin WirknerLIFE - Leipzig Research Centre for Civilization Diseases, Medical Faculty, Leipzig University, Leipzig, Germany.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology (IMISE), Medical Faculty, Leipzig University, Leipzig, Germany. markus.scholz@imise.uni-leipzig.de.ORCID http://orcid.org/0000-0002-4059-1779
Christian FuchsbergerInstitute for Biomedicine, Eurac Research, Bolzano, Italy. Christian.Fuchsberger@eurac.edu.ORCID http://orcid.org/0000-0002-5918-8947

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ARGANI, PEDRAM · 2022 to 2025
$4.7M
Alzheimer's Association AARG-19-616534Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01ZX1906BDeutsche Forschungsgemeinschaft (German Research Foundation) SFB-1052/4 B11Helmholtz Association 01ER2301/14NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917RCUK | Medical Research Council (MRC) MC_UU_00002/7Wellcome TrustWellcome Trust (Wellcome) 225790/Z/22/Z
6 · The paper itself

Abstract

Smelling is a human sense, expressing strong sexual dimorphisms. We aim to improve the knowledge of the genetics of human olfactory perception by performing an exploratory genome-wide association meta-analysis of up to 21,495 individuals of European ancestry. By sex-stratified and overall analysis of the identification of twelve odours and an identification score, we discovered ten independent loci, seven of them novel, with trait-wise genome-wide significance (p < 5 × 10

Indexed as

Genetic VariationGenome-Wide Association StudyOlfactory PerceptionSex CharacteristicsSmellAlzheimer DiseaseFemaleHumansMaleMendelian Randomization AnalysisOdorantsPolymorphism, Single NucleotideReceptors, OdorantWhite PeopleReceptors, Odorant

Identifiers

PMID40593737
PMCPMC12219263

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.