Evidence map›Paper›PMID 40593722›Full record

ArticleNature communications2025

Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging.

Zehong Zhang, Qianyi Wan, Yuedan Zhu, Jinbao Ye, Fang Fu, Xinxin Fan, Haiou Chen, Gang Ren, Wei Jiang, Xiaoxin Guo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Long Noncoding RNANon-coding RNA · 2026
    Article
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  5. Article
  6. Gut metabolism links precision nutrition, exercise, and healthspan inbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zehong Zhang *West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Qianyi Wan *West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-5491-150X
Yuedan Zhu *West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Jinbao Ye *West China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Fang FuWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Xinxin FanWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Haiou ChenWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Gang RenResearch Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang, China.
Wei JiangResearch Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Chinese Medicine, Nanchang, China.
Xiaoxin GuoWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Juanyu ZhouWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
La YanWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Jinhua YanWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Xingzhu LiuWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yu YuanWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Yi ChenDivision of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. toddy@scu.edu.cn.ORCID http://orcid.org/0000-0002-5180-3490
Haiyang ChenWest China Centre of Excellence for Pancreatitis and Laboratory of Metabolism and Aging, Frontiers Science Center for Disease-related Molecular Network and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. chenhy82@scu.edu.cn.ORCID http://orcid.org/0000-0001-8305-4060

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal stem cell (ISC) aging diminishes the regenerative capacity of the intestinal epithelia, but effective therapeutic strategies to counteract human ISC aging remain elusive. Here, we find that the synthesis of α-lipoic acid (ALA) is reduced in old human small intestine. Notably, ALA supplementation inhibits ISC aging and decreases the number of atypical Paneth cells in old human intestinal organoids and in old mouse small intestines. Importantly, we discern that the effect of ALA on mitigating ISC aging is contingent upon the presence of Paneth cells. Inhibiting the mTOR pathway in Paneth cells with ALA or rapamycin significantly increases cyclic ADP ribose (cADPR) secretion and decreases Notum secretion, which, in turn, enhances ISC functions. In this work, our findings substantiate the role of ALA in inhibiting human ISC aging and present a potential therapeutic approach for managing age-related human intestinal diseases.

Indexed as

Cellular SenescencePaneth CellsStem CellsThioctic AcidAgedAgingAnimalsFemaleHumansIntestinal MucosaIntestinesIntestine, SmallMaleMiceMice, Inbred C57BLOrganoidsThioctic AcidTOR Serine-Threonine Kinases

Identifiers

PMID40593722
PMCPMC12215550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.