Evidence map›Paper›PMID 40593719›Full record

ArticleNature communications2025

Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia.

Zhongyu Liu, Lu Xing, Wenlong Huang, Ning Ji, Hang Zhao, Qianming Chen, Xianglong Han, Ding Bai, Xuefeng Zhao

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhongyu LiuState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China.
Lu XingState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China.
Wenlong HuangState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China.ORCID http://orcid.org/0000-0002-8641-7872
Ning JiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China.
Hang ZhaoState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China.ORCID http://orcid.org/0000-0003-1268-0616
Qianming ChenState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China.ORCID http://orcid.org/0000-0002-5371-4432
Xianglong HanState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China.ORCID http://orcid.org/0000-0001-7650-8204
Ding BaiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China. baiding@scu.edu.cn.
Xuefeng ZhaoState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China. zhao.zxf@gmail.com.ORCID http://orcid.org/0000-0001-6860-7739

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81991502National Natural Science Foundation of China (National Science Foundation of China) 82170995National Natural Science Foundation of China (National Science Foundation of China) 82371002National Natural Science Foundation of China (National Science Foundation of China) 82470940
6 · The paper itself

Abstract

Fibrous dysplasia is a skeletal disorder caused by activating mutations in Gα

Indexed as

Cyclic AMP-Dependent Protein KinasesFibrous Dysplasia of BoneAnimalsCell DifferentiationCell ProliferationDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLMice, TransgenicOsteoclastsOsteogenesisProtein Kinase InhibitorsCyclic AMP-Dependent Protein KinasesProtein Kinase Inhibitors

Identifiers

PMID40593719
PMCPMC12219623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.