ArticleNature communications2025
Context flexibly modulates cue representations in visual cortex.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics.bioRxiv : the preprint server for biology · 2025Article
- Context flexibly modulates cue representations in visual cortex.Nature communications · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Learned sensory cues result in enhanced responses in sensory cortices and, in turn, enhanced responses draw attention towards cues in our environment that guide future decision making. To respond appropriately, one must recognize the cue but also the context. Here we use two-photon imaging in visual cortex as mice learn a visual discrimination task and subsequently experience a change in external context through introduction of a threat stimulus. Stimuli associated with a reward elicit an enhanced response due to newly recruited neurons responding preferentially to the rewarded cue in addition to neurons increasing their response magnitude. Introduction of threat results in a largely separate set of neurons encoding cues, but the maintenance of the enhanced response to a rewarded cue. When the threat is relieved, representations revert to their initial state. These data suggest that external context changes can result in rapid but flexible shifts in the representation of visual cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.