ArticleNature communications2025
Noncanonical short-latency auditory pathway directly activates deep cortical layers.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Molecularly Defined Midbrain Circuit Mechanism for Sound-Driven Defensive Behavior and Anxiety.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Natural auditory behaviors invoke cognitive brain networks.Current opinion in neurobiology · 2026Review
- Heritable and experience-dependent cortical traits of reading ability.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Very Early Cortical Auditory Responses to Speech in Humans.bioRxiv : the preprint server for biology · 2026Article
- Ascending inputs to inferior colliculus subdivisions reveal pathway-specific hybrid organization in the external cortex.bioRxiv : the preprint server for biology · 2026Article
- Echoes of the mind's eye: Reciprocal crossmodal interaction between auditory and visual processing.iScience · 2026Article
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9 authors.
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Abstract
Auditory processing in the cerebral cortex is considered to begin with thalamocortical inputs to layer 4 (L4) of the primary auditory cortex (A1). In this canonical model, A1 L4 inputs initiate a hierarchical cascade that propagates to higher-order cortices for slower integration of complex sounds. Here, we identify parallel ascending pathways in mice that bypass A1 and directly reach the secondary auditory cortex (A2), alongside the canonical hierarchical route. We found that layer 6 (L6) of both A1 and A2 receive short-latency (<10 ms) sound inputs via higher-order thalamic nuclei. Additionally, A2 L4 is innervated by a caudal subdivision of the traditionally defined primary thalamus, which we now re-classify as non-primary. Notably, both identified thalamic regions receive projections from distinct subdivisions of the higher-order inferior colliculus, which in turn receive direct projections from cochlear nucleus neurons. Thus, higher-order auditory cortex integrates both slower, pre-processed information and rapid, direct sensory inputs, enabling parallel processing of fast sensory information across cortical areas.
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