Evidence map›Paper›PMID 40593652›Full record

ArticleNature communications2025

Analysis of the Rehmannia chingii geneome identifies RcCYP72H7 as an epoxidase in iridoid glycoside biosynthesis.

Fengqing Wang, Zhennan Jiang, Junge Gao, Chunyan Miao, Ci Song, Yahe Yang, Ning Ding, Yajing Li, Hongzheng Sun, Caixia Xie and 7 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Plant diversity · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Fengqing Wang *College of Agronomy, Henan Agricultural University, Zhengzhou, China. fqwang@henau.edu.cn.ORCID http://orcid.org/0000-0002-7960-6229
Zhennan Jiang *State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Experimental Research Center, China Academy of Chinese Medical Sciences (CACMS), Beijing, China.ORCID http://orcid.org/0009-0001-2455-5487
Junge GaoCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.ORCID http://orcid.org/0009-0002-6158-3548
Chunyan MiaoCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.ORCID http://orcid.org/0009-0007-1113-816X
Ci SongCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.
Yahe YangCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.ORCID http://orcid.org/0009-0006-2581-2541
Ning DingCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.ORCID http://orcid.org/0009-0000-2487-873X
Yajing LiInstitute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Hongzheng SunCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.
Caixia XieSchool of Medicine, Henan University of Chinese Medicine, Zhengzhou, China.ORCID http://orcid.org/0009-0006-3010-2974
Bao ZhangSchool of Medicine, Henan University of Chinese Medicine, Zhengzhou, China.ORCID http://orcid.org/0009-0006-3105-5559
Pengyu ZhangCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.ORCID http://orcid.org/0009-0000-9073-5796
Li GuCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou, China.ORCID http://orcid.org/0000-0001-9072-4704
Qiuwen HaoCollege of Agronomy, Henan Agricultural University, Zhengzhou, China.ORCID http://orcid.org/0009-0007-6231-7926
Zhongyi ZhangCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou, China.
Luqi HuangState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Experimental Research Center, China Academy of Chinese Medical Sciences (CACMS), Beijing, China. huangluqi01@126.com.
Yuan YuanState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Experimental Research Center, China Academy of Chinese Medical Sciences (CACMS), Beijing, China. y_yuan0732@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rehmannia chingii (2n = 2x = 28) is an important folk medicinal plant with high therapeutic value, particularly due to its richness in iridoid glycosides. However, research on its evolution and gene functional identification has been hindered by the lack of a high-quality genome. Here, we present the 1.169 Gb telomere-to-telomere (T2T) genome sequence of R. chingii. Phylogenetic analysis confirms that Rehmannia belongs to the Orobanchaceae family. We find that structural genes of the 2-C-methyl-d-erythritol-4-phosphate (MEP) pathway and the iridoid pathway are predominantly expressed in R. chingii leaves. Further analyses reveal a cytochrome P450 gene cluster localized on chromosome 8, and identify RcCYP72H7 within this cluster as an aucubin epoxidase, capable of catalyzing aucubin epoxidation to form catalpol. The genome offers valuable resources for studying iridoid glycoside biosynthesis and the evolutionary history of Rehmannia, and will help to faciliate genetic improvement of R. chingii for pharmaceutical and health-related applications.

Indexed as

Iridoid GlycosidesPlant ProteinsRehmanniaCytochrome P-450 Enzyme SystemGene Expression Regulation, PlantGenome, PlantIridoid GlucosidesMultigene FamilyPhylogenyPlant LeavescatalpolCytochrome P-450 Enzyme SystemIridoid GlucosidesIridoid GlycosidesPlant Proteins

Identifiers

PMID40593652
PMCPMC12214713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.