Evidence map›Paper›PMID 40593620›Full record

ArticleNature communications2025

Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer.

Joseph Zenga, Musaddiq J Awan, Anne Frei, Jamie Foeckler, Rachel Kuehn, Julia Kasprzak, Becky Massey, Jennifer Bruening, Kenneth Akakpo, Monica Shukla and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Joseph ZengaDepartment of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA. jyzenga@mcw.edu.ORCID http://orcid.org/0000-0003-1565-9628
Musaddiq J AwanDepartment of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA.
Anne FreiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WIh, USA.
Jamie FoecklerDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WIh, USA.
Rachel KuehnDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WIh, USA.ORCID http://orcid.org/0009-0002-5862-250X
Julia KasprzakDepartment of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.
Becky MasseyDepartment of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA.
Jennifer BrueningDepartment of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA.
Kenneth AkakpoDepartment of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA.
Monica ShuklaDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WIh, USA.
Stuart J WongCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Angela J MathisonCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-6763-2710
Jaime Wendt AndraeCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Bryan HuntCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Andrii PuzyrenkoCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Victor X JinCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-8765-3471
Abdullah A MemonMedical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0009-0009-9062-7619
Oscar Villarreal EspinosaMedical College of Wisconsin, Milwaukee, WI, USA.
Fanghong ChenCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Md ShaheduzzamanCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Tyce KearlCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.
Peiman HemattiCancer Center, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-5836-4497
Heather A HimburgDepartment of Otolaryngology, Medical College of Wisconsin, Milwaukee, WI, USA. hhimburg@mcw.edu.ORCID http://orcid.org/0000-0002-9676-6371

Funding

Leveraging single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral cancerR01DE034360 · NIDCR · MEDICAL COLLEGE OF WISCONSIN · PI Tyce Jeffrey Kearl, Joseph Zenga · 2025 to 2026
$780k
Determining the role of the SDF-1/CXCR4 pathway and its intersection with chronic stress to establish novel precision approaches to head and neck cancer managementR21CA279935 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI ZENGA, JOSEPH · 2023 to 2024
$392k
NCI NIH HHS R21 CA279935NIDCR NIH HHS R01 DE034360U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DE034360U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21CA279935
6 · The paper itself

Abstract

Human Papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy, with radiotherapy, alone or combined with immune checkpoint inhibitors, often failing to achieve durable disease control. Here, by conducting longitudinal multi-omic analyses of pre- and post-radiation biopsies from patients receiving a pre-operative hypofractionated radiation regimen, we uncover that radiation rapidly depletes a subpopulation of tumor-infiltrating lymphocytes (TIL), characterized by a proliferative, cytotoxic, and tissue-resident gene signature (T

Indexed as

Antigens, NeoplasmHead and Neck NeoplasmsLymphocytes, Tumor-InfiltratingSquamous Cell Carcinoma of Head and NeckAgedFemaleHumansMaleMiddle AgedTumor MicroenvironmentAntigens, Neoplasm

Identifiers

PMID40593620
PMCPMC12219838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.