ArticleNature communications2025
CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.Cell death and differentiation · 2026Article
- CFAP100 forms phase-separated condensates required for ciliary transition zone assembly.Nature communications · 2026Article
- ENKD1 Modulates Skin Elasticity Through Microtubule Stability Regulation.Cytoskeleton (Hoboken, N.J.) · 2026Article
- Filippi syndrome-associated CKAP2L modulates microtubule dynamics essential for mitosis and ciliary length regulation.Journal of molecular cell biology · 2026Article
- USP21-mediated deubiquitylation stimulates NuMA recruitment to the cell cortex to promote mitotic spindle orientation.Cell death and differentiation · 2026Article
- pH-modulating binary hydrogen-bonded organic frameworks accelerate diabetic wound healing.Journal of nanobiotechnology · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Despite the importance of keratinocytes in epidermal structure and function, the molecular mechanisms regulating the division of these cells remain poorly understood. Herein, we demonstrate an essential role for cilia and flagella associated protein 100 (CFAP100) in keratinocyte division. Cfap100-knockout mice display a thinner and transparent skin and an impaired epidermal barrier function. Depletion of CFAP100 in keratinocytes prolongs mitotic progression and compromises chromosome segregation. Molecular studies reveal that CFAP100 interacts with tubulin tyrosine ligase-like protein 13 (TTLL13) to maintain spindle pole integrity in dividing keratinocytes. Further analysis shows that CFAP100 recruits TTLL13 to the spindle pole to increase the glutamylation of spindle microtubules. Restoring microtubule glutamylation by overexpression of TTLL13 or depletion of cytosolic carboxypeptidase 5 remarkably rescues the spindle pole defects in CFAP100-depleted cells. These findings thus identify CFAP100 as a central link to couple microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development.
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Registered trials
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