ArticleNature communications2025
Rim4-seeded stress granules connect temperature sensing to meiotic regulation.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Cross-species rescue reveals sequence requirements for a rapidly evolving intrinsically disordered region.PLoS biology · 2025Article
- Methyladenine as a regulator of biomolecular condensation.Frontiers in molecular biosciences · 2025Review
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Authors and funding
6 authors.
Funding
Abstract
Meiosis is more vulnerable to heat than mitosis in many species including humans. In Saccharomyces cerevisiae, we discovered that stress granule formation halts meiosis at high temperatures. Meiotic stress granules appear at lower temperatures (33-42 °C) than mitotic stress granules (~46 °C), requiring the meiosis-specific RNA binding protein Rim4. Heat triggers site-specific Rim4 dephosphorylation, causing it to self-assemble into stress granule seeds. These recruit other stress granule components like Pab1 and mRNAs, pausing meiosis. Normally, 14-3-3 proteins block this assembly by binding phosphorylated Rim4. After temperature drops, Hsp104 assists to break down stress granules. Longer stress granule persistence correlates with better recovery, suggesting stress granules might provide temporal insulation for cellular repair processes prior to meiotic resumption.
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