Evidence map›Paper›PMID 40593548›Full record

ArticleNature communications2025

Commitment of adipose-resident c-kit

Qishan Chen, Ya Yu, Run Zhang, Qiaohang Zhao, Danqing Yu, Chun Feng, Jiaojiao Zhou, Meng Luo, Mei Yang, ShaSha Sun and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qishan Chen *Department of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. lastufo@hotmail.com.
Ya Yu *Department of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Run Zhang *Institute for Cardiovascular Development and Regenerative Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0009-0001-4067-0880
Qiaohang ZhaoDepartment of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Danqing YuDepartment of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Chun FengDepartment of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Jiaojiao ZhouThe Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0003-0442-6183
Meng LuoThe Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Zhejiang University School of Medicine, Hangzhou, China.
Mei YangInstitute for Cardiovascular Development and Regenerative Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
ShaSha SunInstitute for Cardiovascular Development and Regenerative Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Li ZhangInstitute for Cardiovascular Development and Regenerative Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. li.zhang@shsmu.edu.cn.
Min JinDepartment of Reproductive Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. min_jin@zju.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81971350National Natural Science Foundation of China (National Science Foundation of China) 82125005National Natural Science Foundation of China (National Science Foundation of China) 82270430National Natural Science Foundation of China (National Science Foundation of China) 82470349Natural Science Foundation of Shanghai (Natural Science Foundation of Shanghai Municipality) 22ZR1480000Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LR20H020001
6 · The paper itself

Abstract

The global incidence of obesity-related metabolic disorders and their comorbidities continue to increase along with a demand for innovative therapeutic interventions. An in-depth understanding of de novo thermogenic adipogenesis is vital to harness the potential of these adipocytes. Here, we combine genetic lineage tracing and single-nucleus RNA sequencing to demonstrate that adult adipose-resident c-kit

Indexed as

Adipocytes, BrownAdipose Tissue, BrownProto-Oncogene Proteins c-kitStem CellsAdipocytes, WhiteAdipogenesisAdipose Tissue, WhiteAnimalsCell DifferentiationCell LineageDiet, High-FatFemaleHomeostasisMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-kit

Identifiers

PMID40593548
PMCPMC12216703

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.