Evidence map›Paper›PMID 40593533›Full record

ArticleNature communications2025

Structural basis of voltage-dependent gating in BK channels.

Gustavo F Contreras, Rong Shen, Ramon Latorre, Eduardo Perozo

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Potential therapeutic targeting of BKMolecular oncology · 2026
    Review
  4. Article
  5. Article
  6. Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Tuning the gate and the gear: The LRRC26 (bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gustavo F ContrerasDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0000-4619-4726
Rong ShenDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Ramon LatorreCentro Interdisciplinario de Neurociencia, Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.ORCID http://orcid.org/0000-0002-6044-5795
Eduardo PerozoDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA. eperozo@uchicago.edu.ORCID http://orcid.org/0000-0001-7132-2793

Funding

The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
Structural Basis of Coupling and Dynamics in K+ ChannelsR01GM150272 · NIGMS · UNIVERSITY OF CHICAGO · PI Eduardo A Perozo · 2023 to 2026
$2.2M
Beagle-3: A Shared GPU Cluster for Biomolecular SciencesS10OD028655 · OD · UNIVERSITY OF CHICAGO · PI ROUX, BENOIT · 2020 to 2020
$2.0M
NIGMS NIH HHS R01 GM030376NIGMS NIH HHS R01 GM150272NIH HHS S10 OD028655U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM150272
6 · The paper itself

Abstract

The allosteric communication between the pore domain, voltage sensors, and Ca

Indexed as

Ion Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsAnimalsAplysiaBinding SitesCalciumCryoelectron MicroscopyModels, MolecularMutationProtein DomainsCalciumLarge-Conductance Calcium-Activated Potassium Channels

Identifiers

PMID40593533
PMCPMC12218146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.