Evidence map›Paper›PMID 40593485›Full record

ArticleTranslational psychiatry2025

Nucleus accumbens dynamics in food reward seeking and regulation by sleep.

Ana L Almeida Rojo, Li Cai, Tyler R Barnhardt, Yanhua H Huang

Abstract read
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Sleep deprivation engages the orexin/hypocretin system to regulate food reward seeking.The international journal of neuropsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ana L Almeida RojoDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Li CaiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Tyler R BarnhardtDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Yanhua H HuangDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA. yhhuang@pitt.edu.ORCID http://orcid.org/0000-0003-1770-0196

Funding

Subject Management and BiobankingP50DA046346 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, Colleen A McClung · 2020 to 2026
$23.4M
Sleep regulates drug relapse and addictionR01DA046491 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, YANHUA H · 2019 to 2023
$1.8M
Developing a sleep EEG-based biomarker for drug relapse propensityR01DA057954 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yanhua H Huang · 2024 to 2026
$1.6M
NIDA NIH HHS P50 DA046346NIDA NIH HHS R01 DA046491NIDA NIH HHS R01 DA057954U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA046346U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) DA046491
6 · The paper itself

Abstract

Reward-seeking behavior is essential for survival and is greatly influenced by experience, internal states, and physiological factors such as sleep. The nucleus accumbens (NAc) is reward processing hub that integrates external and internal signals to regulate reward-seeking behaviors. However, it is not well understood how NAc activities during reward seeking may be shaped by learning experience, and to what extent that it may be subject to physiological regulations such as sleep. Here, we used in vivo fiber photometry to monitor calcium (Ca

Indexed as

Behavior, AnimalNucleus AccumbensRewardSleepSleep DeprivationAnimalsCalciumFemaleMaleMiceMice, Inbred C57BLSelf AdministrationSucroseCalciumSucrose

Identifiers

PMID40593485
PMCPMC12218339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.