Evidence map›Paper›PMID 40593462›Full record

ArticleTranslational psychiatry2025

The murine ATP-binding cassette transporter C5 (Abcc5/MRP5/cMOAT) plays a role in memory consolidation, circadian rhythm regulation and glutamatergic signalling.

Gareth Banks, Malgorzata Cyranka, Natascia Vedovato, Charlotte Meller, Alex Rawnsley, Edward O Mann, Michelle Stewart, Heidi de Wet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. An Emerging Paradigm for ABCC5/MRP5 Function in Human Physiology.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gareth BanksSchool of Science and Technology, Nottingham Trent University, Nottingham, UK.ORCID http://orcid.org/0000-0002-8647-667X
Malgorzata CyrankaDept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, UK.
Natascia VedovatoDept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, UK.ORCID http://orcid.org/0000-0003-4462-5865
Charlotte MellerDept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, UK.
Alex RawnsleyDept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, UK.ORCID http://orcid.org/0009-0007-5894-1558
Edward O MannDept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, UK.ORCID http://orcid.org/0000-0002-2468-7148
Michelle StewartMRC Harwell Institute, Mary Lyon Centre, Harwell Campus, Didcot, Oxfordshire, UK.
Heidi de WetDept of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, UK. Heidi.de-wet@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0002-9871-6909

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/P020666/1Wellcome Trust (Wellcome) 218482/Z/19/Z
6 · The paper itself

Abstract

ATP-Binding cassette (ABC) transporters are a family of integral membrane ATPases that transport a large number of structurally unrelated compounds. The physiological role of the orphan transporter Abcc5 remains poorly understood. As previous work demonstrated that the loss of Abcc5 activity leads to elevated levels of NAAG in the brain, the impact of Abcc5 ablation was ascertained using behavioural phenotyping, circadian rhythm analysis and electrophysiological recordings of brain slices from Abcc5

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsCircadian RhythmGlutamic AcidMemoryAnimalsBehavior, AnimalExcitatory Postsynaptic PotentialsMaleMiceMice, Inbred C57BLMice, KnockoutPyramidal CellsSignal TransductionSleepATP-Binding Cassette, Sub-Family C ProteinsGlutamic Acid

Identifiers

PMID40593462
PMCPMC12214961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.