Evidence map›Paper›PMID 40593441›Full record

ArticleFolia microbiologica2026

Constitutive ALS3 expression in Candida albicans has differential effects on yeast-locked tet-NRG1 and brg1Δ strains.

Nicholas C Schena, Kassandra M Baker, Anna A Stark, Derek P Thomas, Ian A Cleary

Abstract read
PubMed Publisher
In one paragraph

Article in Folia microbiologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas C SchenaDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA.
Kassandra M BakerDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA.
Anna A StarkDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA.
Derek P ThomasDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA.
Ian A ClearyDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA. clearyia@gvsu.edu.ORCID http://orcid.org/0000-0002-3958-431X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fungal pathogen Candida albicans produces numerous surface proteins involved in adhesion. Many of these adhesins are specific to different morphological forms. Strains that are unable to form hyphae are generally impaired in their ability to adhere to surfaces and to form biofilms. To better understand the function of one of these adhesins, Als3p, in the context of yeast-locked strains, we expressed ALS3 in strains with altered expression of one of two genes that are part of a regulatory circuit, BRG1 and NRG1. The mutant BRG1 and NRG1 strains we examined were phenotypically similar. We observed that ALS3 expression improved the adhesion of both strains to glass but that only one had altered biofilm forming ability, which was decreased.

Indexed as

Candida albicansFungal ProteinsTranscription FactorsBiofilmsCell AdhesionDNA HelicasesGene Expression Regulation, FungalALS3 protein, Candida albicansDNA HelicasesFungal ProteinsTranscription FactorsAdhesionALS3BiofilmsBRG1Candida albicansNRG1

Identifiers

PMID40593441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.