ArticleMethods in molecular biology (Clifton, N.J.)2025
Competitive Epitope Binning Using HT-SPR.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Human neutralizing antibodies targeting the measles virus hemagglutinin and fusion surface proteins.Cell host & microbe · 2026Article
- Monoclonal antibody passive experimental autoimmune myasthenia gravis: current progress and future directions.Cell & bioscience · 2026Review
- Nanobodies against Clostridioides difficile CDTb provide a toolkit for potent toxin neutralization and highly sensitive quantitation.The Journal of biological chemistry · 2026Article
- Protein-Ligand Interactions: Recent Advances in Biophysics, Biochemistry, and Bioinformatics.International journal of molecular sciences · 2025Article
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Authors and funding
3 authors.
Funding
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Abstract
Competitive epitope binning using high-throughput surface plasmon resonance (HT-SPR) is a method for understanding competitive epitope profiles of up to hundreds of monoclonal antibodies. Detailed here is an approach along with considerations for the design and analysis of a classical competitive epitope binning assay using the Carterra LSA. Monoclonal antibodies are arrayed on a biosensor chip and interrogated serially for their ability to form a trimolecular complex with antigen and solution phase monoclonal antibodies. Software tools allow the clustering of monoclonal antibodies sharing common epitopes, and the real-time nature of the data allows for study of binding profiles for each monoclonal antibody.
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