Evidence map›Paper›PMID 40593396›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Intracytoplasmic Sperm Injection (ICSI) Timing Affects the Influence of Sperm DNA Fragmentation on ICSI Outcomes.

Gaofeng Yan, Dan Tang, Zhenfang Su, Longda Wang, Youlin Yao, Wenjuan Yang, Ling Lu, Xiufang Gui, Huawei Wang, Shuhua Zhao

Abstract read
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In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gaofeng Yan *Reproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Dan Tang *Department of Obstetrics, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Zhenfang Su *Reproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Longda WangReproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Youlin YaoReproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Wenjuan YangReproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Ling LuReproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Xiufang GuiReproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China.
Huawei WangReproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China. wanghuawei99@163.com.
Shuhua ZhaoReproductive Genetics Department, The first affiliated hospital of Kunming Medical University, Kunming, 650032, China. kmshh1982@126.com.ORCID 0000-0003-4698-4140

Funding

535 Talent Project of the First Affiliated Hospital of Kunming Medical University 2023535D01Basic Project of Yunnan Province 202301AS070017Kunming Medical University CXTD202105
6 · The paper itself

Abstract

Oocytes have repair ability for paternally derived DNA damage which depends on oocyte quality. Prolonged post ovum pick-up (OPU) incubation may lead to oocyte aging, which is linked to changes in oocyte ultrastructure and function. In order to study whether the effect of sperm DNA fragmentation (SDF) on intracytoplasmic sperm injection (ICSI) outcomes influenced by ICSI timing, we conducted this retrospective study included 1,331 ICSI cycles from March 2016 to December 2022. Outcomes were compared between two groups (an SDF level < 30% group and an SDF level ≥ 30% group) at different tertiles, which were based on OPU-ICSI time. There were no significant between-group differences in the overall laboratory and clinical outcomes (all p > 0.05). However, the clinical pregnancy rates (CPRs) (28.6% vs. 40.9%, p = 0.017) and live birth rates (LBRs) (21.4% vs. 33.4%, p = 0.014) were significantly lower in the SDF level ≥ 30% group than in the SDF level < 30% group in tertile 3. After adjusting for confounders, these differences remained significant, as shown by odds ratios (ORs) (95% confidence intervals (CIs)) of 0.425 (0.244, 0.742) for CPR and 0.485 (0.272, 0.865) for LBR. Significant between-tertile differences in outcomes were only found in the SDF level ≥ 30% group. In conclusion, ICSI timing affects the influence of SDF on the probability of live birth in women undergoing ICSI treatment. Therefore, in patients with high SDF levels, the optimal timing of ICSI should be determined.

Indexed as

DNA FragmentationSpermatozoaSperm Injections, IntracytoplasmicAdultFemaleHumansMalePregnancyPregnancy RateRetrospective StudiesTime FactorsTreatment OutcomeICSIICSI timingLive birthOocyte ageingSperm DNA fragmentation

Identifiers

PMID40593396

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.