Evidence map›Paper›PMID 40593386›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2025

Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection.

Tzu-Hao Lee, Kara Wegermann, Rachel Safeek, Meredith Mock, Sam Lusk, Lisa St John-Williams, Will J Thompson, Joseph E Lucas, M Arthur Moseley, Keyur Patel and 1 more

Abstract read
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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tzu-Hao LeeSection of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, 6620 Main Street, Suite 1450, Houston, TX, 77030, USA. Howard.Lee@bcm.edu.
Kara WegermannDivision of Gastroenterology, Department of Medicine, Duke University Health System, Durham, NC, USA.
Rachel SafeekDepartment of Surgery, University of Florida, Gainesville, FL, USA.
Meredith MockThe George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Sam LuskDuke Clinical Research Institute, Durham, NC, USA.
Lisa St John-WilliamsDuke Center for Genomic and Computational Biology, Durham, NC, USA.
Will J ThompsonDuke Center for Genomic and Computational Biology, Durham, NC, USA.
Joseph E LucasVital Statistics LLC, Chapel Hill, USA.
M Arthur MoseleyDuke Center for Genomic and Computational Biology, Durham, NC, USA.
Keyur PatelDivision of Gastroenterology and Hepatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Susanna NaggieDivision of Infectious Diseases, Department of Medicine, Duke University Health System, Durham, NC, USA.

Funding

Moving Towards More Individualized Therapies in HIV/HCV Co-infected PatientsK23AI096913 · NIAID · DUKE UNIVERSITY · PI NAGGIE, SUSANNA · 2011 to 2014
$355k
National Institute of Allergy and Infectious Diseases K23AI096913NIAID NIH HHS K23 AI096913
6 · The paper itself

Abstract

Non-invasive assessments for advanced liver fibrosis have limited accuracy in persons with human immunodeficiency virus (HIV) (PWH) who have hepatitis C virus (HCV) co-infection, and new tools are needed. Our aim was to discover oxylipin profiles associated with advanced liver fibrosis in treatment-naïve patients with HIV/HCV co-infection. Serum samples from 40 PWH with HCV were subjected to targeted oxylipin analysis. A model with AST and seven metabolites, including 5(S)-HEPE, 8-HETE, 14,15-DiHETrE, 4-HDoHE, 14- HDoHE, 7-HDoHE, and 9,10-DiHOME yielded an area under the receiver operating characteristic curve of 0.93, with optimal sensitivity and specificity of 86% and 88%, respectively.

Indexed as

CoinfectionHepatitis CHIV InfectionsLipidsLiver CirrhosisAdultBiomarkersFemaleHepacivirusHumansMaleMiddle AgedOxylipinsBiomarkersLipidsOxylipinsCoinfectonEicosanoidFibrosisHepatitis C virusHIVMetaboliteMetabolomicsOxylipin

Identifiers

PMID40593386
PMCPMC13621720

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.