Evidence map›Paper›PMID 40593338›Full record

SynthesisNeurosurgical review2025

A systematic review evaluating the effectiveness of nuclear medicine techniques in enhancing the diagnostic accuracy of stereotactic brain biopsies.

Athanasios Gkampenis, Eleni Romeo, Ioannis Koukoulithras, Marios Lampros, Spyridon Voulgaris, Andreas G Tzakos, George A Alexiou

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Athanasios GkampenisDepartment of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece.
Eleni RomeoDepartment of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece.
Ioannis KoukoulithrasDepartment of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece.
Marios LamprosDepartment of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece.
Spyridon VoulgarisDepartment of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece.
Andreas G TzakosDepartment of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110, Ioannina, Greece.
George A AlexiouDepartment of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece. galexiou@uoi.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of the present systematic review is to assess the effectiveness of nuclear medicine methods to improve the diagnostic accuracy of stereotactic brain biopsies (SBB).

methodsA search in Medline, Cochrane, and Scopus databases until 22

resultsThirteen studies (9 prospective and 4 retrospective) with a total of 337 patients were included in this systematic review. There was a high risk of bias at least in one domain in all studies, while in 4 studies there were high concerns regarding applicability at least in one domain. Positron emission tomography (PET) was used in 12 studies and single photon emission computed tomography (SPECT) in 1 study to design the trajectories of the biopsies. A diagnosis was established through SBB in 282 out of 291 patients, while for the remaining 46 patients there was no relevant data in the studies. Two studies provided data on sensitivity (76 - 81.2 %), specificity (50 - 80 %), and Area Under the Curve (AUC) (56.2 - 89 %).

conclusionNuclear medicine has the potential to increase the diagnostic accuracy of SBB by improving targeting precision. Among the radiotracers,

Indexed as

BrainBrain NeoplasmsNuclear MedicineStereotaxic TechniquesBiopsyHumansPositron-Emission TomographyTomography, Emission-Computed, Single-PhotonDiagnostic accuracyNuclear medicinePositron emission tomographySingle photon emission computed tomographyStereotactic brain biopsies

Identifiers

PMID40593338

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.