Evidence map›Paper›PMID 40593310›Full record

ReviewApplied microbiology and biotechnology2025

Nipah virus: pathogenesis, genome, diagnosis, and treatment.

Rishav Madhukalya, Urvashi Yadav, Hilal Ahmad Parray, Nisha Raj, Santhik Subhasingh Lupitha, Vivek Kumar, Anjali Saroj, Vidushi Agarwal, Dilip Kumar, Supratik Das and 1 more

Abstract readReview
In one paragraph

Review in Applied microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Andes Virus: From Transmission Dynamics to Pandemic Potential.European journal of clinical investigation · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rishav MadhukalyaDepartment of Biosciences and Bioengineering, Indian Institute of Technology (IIT), 247667, Roorkee, India.
Urvashi YadavDepartment of Biosciences and Bioengineering, Indian Institute of Technology (IIT), 247667, Roorkee, India.
Hilal Ahmad ParrayTranslational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana- 121001, India.
Nisha RajTranslational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana- 121001, India.
Santhik Subhasingh LupithaInstitutes of Advanced Virology, Bio 360 Life Science Park, Trivandrum, Kerala- 695317, India.
Vivek KumarDepartment of Biosciences and Bioengineering, Indian Institute of Technology (IIT), 247667, Roorkee, India.
Anjali SarojDepartment of Biosciences and Bioengineering, Indian Institute of Technology (IIT), 247667, Roorkee, India.
Vidushi AgarwalDepartment of Biosciences and Bioengineering, Indian Institute of Technology (IIT), 247667, Roorkee, India.
Dilip KumarTrivedi School of Biosciences, Ashoka University, Sonipat, Haryana, India.
Supratik DasTranslational Health Science & Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana- 121001, India. supratik@thsti.res.in.
Rajesh KumarDepartment of Biosciences and Bioengineering, Indian Institute of Technology (IIT), 247667, Roorkee, India. rajesh.kumar@bt.iitr.ac.in.ORCID http://orcid.org/0000-0002-6744-0241

Funding

LifeArc LDIA-Proj# 10720
6 · The paper itself

Abstract

The highly infectious Nipah virus (NiV) is classified under the Paramyxoviridae family and is categorized under the genus Henipavirus. NiV spreads to humans through zoonotic transmission from reservoir host bats and other intermediate hosts. It is highly contagious and has a high case fatality rate (CFR) of ~ 40-80%. Only sporadic outbreaks have been reported so far, but like SARS-CoV2, NiV has a high pandemic potential and has been put on the World Health Organization (WHO) priority pathogen list. Currently, no clinically approved antivirals, immunotherapy, or vaccines are available to tackle NiV infection, thereby necessitating further research into its life cycle, transmission, and pathogenesis. This detailed review outlines the origin and spread of the Nipah virus, its modes of transmission, risk factors, its genome, key proteins, pathogenesis, and clinical features. We also discuss different diagnostic approaches and ongoing research to develop therapies ranging from antibodies to vaccines. KEY POINTS: •Pandemic preparedness for emerging and re-emerging viruses. •Novel approaches for diagnostics and therapeutics for Nipah viruse. •Global threat from biosafety level 4 pathogens. •Animal models for Nipah virus research.

Indexed as

Genome, ViralHenipavirus InfectionsNipah VirusAnimalsAntiviral AgentsChiropteraHumansZoonosesAntiviral AgentsAnti-viral drugsClinical trialsHenipavirusNipah virusVaccinesViral encephalitisViral outbreaksWHO

Identifiers

PMID40593310
PMCPMC12214056

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.