Evidence map›Paper›PMID 40593254›Full record

ArticleScientific reports2025

Primary sjögren's syndrome among patients with cerebral infarction.

Liping Fan, Chen Wang, Zhenzhen Yu, Yihong Zhan

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Liping Fan *Department of Neurology, Xiamen Xinglin Hospital, Xiamen, 361000, China.
Chen Wang *Department of Neurology, Fujian Psychiatric Center, Xiamen Xianyue Hospital, Xianyue Hospital Affiliated with Xiamen Medical College, Fujian Clinical Research Center for Mental Disorders, Xianyue Road No. 387, Xiamen, 361000, Fujian, China. wangchen1986xm@163.com.
Zhenzhen YuDepartment of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Shengguang Road No. 566, Jimei District, Xiamen, 361000, Fujian, China. 350677526@qq.com.
Yihong ZhanDepartment of Neurology, Department of Neuroscience, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Zhenhai Road No.55, Siming District, Xiamen, 361000, China. yihongzhan31@163.com.

Funding

Natural Science Fund of Fujian province 2023J011622Natural Science Fund of Xiamen 3502Z20224ZD1259Xiamen Health High quality development science and technology program medical innovation project funding 2024GZL-CX38
6 · The paper itself

Abstract

To investigate the clinical features, treatment, and outcomes in cerebral infarction (CI) patients with Sjögrens syndrome (pSS) for novel disease management strategies. A total of 27 patients diagnosed with CI with pSS were divided into the treatment group (12 patients) and non-treatment group (15 patients) according to whether they were treated for pSS in the acute and secondary prevention stage of CI. The related clinicopathological information including age, gender, medical history, experimental data, clinical manifestations, imaging data, treatment, functional recovery and recurrences were retrospectively analyzed. The clinical manifestations of 27 CI patients with pSS varied widely. There were also no significant differences in age, gender, traditional high-risk factors of CI, previous history, experimental data, and short-term nerve functional recovery between the two groups (p > 0.05). After 1 year of treatment, timely treatment of pSS can significantly improve the prognosis, the favorable prognosis (modified Rankin scale ≤ 2) of the treatment and non-treatment groups were 83.3% and 40.0% respectively. The recurrence rate of CI was 0% in the treatment group but 33.3% in the non-treatment group. Compared to the no treatment group. The odds of achieving a favorable prognosis in the treatment group were 7.5 times higher than in the non-treatment group (OR = 7.5, 95% CI: 1.195-47.1). the adjusted odds ratio was 0.113 (95% CI: 0.002-1.214). This indicates an 89% reduction in recurrence odds with treatment. PSS screening is necessary for CI patients. Moreover, prompt pSS treatment administered during the acute and secondary prevention stage of CI with pSS can promote neurologic functional independence and reduce the risk of CI recurrent.

Indexed as

Cerebral InfarctionSjogren's SyndromeAdultAgedFemaleHumansMaleMiddle AgedPrognosisRecurrenceRetrospective StudiesRisk FactorsTreatment OutcomeCerebral infarctionClinical manifestationImmunomodulatory treatmentPrognosisSjögren syndrome

Identifiers

PMID40593254
PMCPMC12217698

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