Evidence map›Paper›PMID 40593228›Full record

ArticleScientific reports2025

Uncovering pleiotropic loci in allergic rhinitis and leukocyte traits through multi-trait GWAS.

Liulin Yang, Bichen Peng, Yuanning Wu, Weiyi Ye, Xianjin Wang, Qingyi Zhang, Ziang Meng, Qinfeng Wu, Yue Jiang, Linzehao Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Liulin Yang *Electrical Engineering College, Guangxi University, Nanning, 530004, China.
Bichen Peng *College of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Yuanning Wu *Department of Respiratory, Linyi Central Hospital, Linyi, 276401, China.
Weiyi YeCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Xianjin WangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Qingyi ZhangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Ziang MengCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Qinfeng WuCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Yue JiangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Linzehao LiCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Yingchao SongCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China.
Lili ZhiDepartment of Allergy, Shandong Institute of Respiratory Diseases, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China.
Xiao ChangCollege of Medical Information and Artificial Intelligence, Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong, 250117, China. changxiao@sdfmu.edu.cn.
Liang DongDepartment of Respiratory, Shandong Institute of Respiratory Diseases, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China. dl5506@126.com.
Lei ShaoDepartment of Infectious Disease, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China. shaolei0328@163.com.

Funding

Excellent Youth Science Fund Project (Overseas) of Shandong China 2023HWYQ-082Shandong Province Higher Education Institution Youth Innovation and Technology Support Program 2023KJ179the National Natural Science Foundation of China 32270661the Special Funds of Taishan Scholar Project, China tsqn202211224
6 · The paper itself

Abstract

Allergic rhinitis (AR) is a nasal inflammation triggered by the immune system's response to airborne allergens, with white blood cells playing a crucial role in the development of allergic symptoms. This study aimed to investigate the genetic correlations between AR and various blood traits in European and East Asian populations using linkage disequilibrium score regression (LDSC). By leveraging GWAS summary statistics, we identified significant genetic overlap between AR and eosinophil counts in both populations. Cross-trait analysis revealed 52 pleiotropic loci associated with AR and eosinophil counts in Europeans, while 12 novel loci were discovered in East Asians. Among these, five loci, including IL1RL1 and IL4R, were shared between Europeans and East Asians. Additionally, we identified a novel East Asian-specific locus near the CD28 gene. Differential gene expression analysis further showed that CD28 expression was significantly lower in AR patients compared to healthy controls, suggesting its potential involvement in AR pathogenesis. These findings underscore the utility of multi-trait GWAS in uncovering pleiotropic loci and provide new insights into the genetic architecture of AR, particularly emphasizing population-specific loci like CD28. This research opens avenues for understanding the genetic basis of AR and developing targeted therapies.

Indexed as

Genetic PleiotropyGenome-Wide Association StudyLeukocytesQuantitative Trait LociRhinitis, AllergicAdultCD28 AntigensEast Asian PeopleFemaleGenetic Predisposition to DiseaseHumansLinkage DisequilibriumMalePolymorphism, Single NucleotideWhite PeopleCD28 AntigensAllergic rhinitisGenetic correlationGenome-wide association study

Identifiers

PMID40593228
PMCPMC12218862

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