Evidence map›Paper›PMID 40593206›Full record

ReviewResults and problems in cell differentiation2025

Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer.

Andrew J Fritz, Kyle T McKay, Haley W Greenyer, Emory Pacht, Rabail H Toor, Rahim Ullah, Jackson R Del Porto, Abigail G Person, Sadie J Korzec, Kathleen E Bright and 10 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Results and problems in cell differentiation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Andrew J FritzDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Kyle T McKayUniversity of Vermont Cancer Center, University of Vermont, Burlington, VT, USA.
Haley W GreenyerDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Emory PachtDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Rabail H ToorDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Rahim UllahDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Jackson R Del PortoDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Abigail G PersonDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Sadie J KorzecDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Kathleen E BrightDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Genevieve BrzozaDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Jessica L HeathDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Prachi N GhuleDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Jonathan A R GordonDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Andre J Van WijnenDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Seth E FrietzeDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Karen C GlassDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Jane B LianDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Janet L SteinDepartment of Biochemistry, University of Vermont, Burlington, VT, USA.
Gary S SteinDepartment of Biochemistry, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.

Funding

Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast CancerP01CA240685 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI STEIN, JANET L · 2021 to 2025
$8.7M
NCI NIH HHS P01 CA240685
6 · The paper itself

Abstract

Acetylation of histones epigenetically mediates transcriptional dynamics of gene activation and suppression in response to physiological regulatory signals. The acetylated states of histone proteins define the activities of gene promoter and enhancer elements by contributing to competency for regulatory protein interactions and control of chromatin organization including higher-order inter and intra-chromosomal interactions. Cell transformation and tumor progression are associated with and functionally related to histone acetylation. Targeting the regulatory machinery for histone acetylation provides treatment options for cancer-compromised gene expression with specificity and reduced off-target consequences.

Indexed as

Epigenesis, GeneticHistonesNeoplasmsAcetylationAnimalsHumansHistonesAcetylationEpigenetic controlHigher-order chromatin organizationPost-translational histone modificationsTranscription

Identifiers

PMID40593206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.