Evidence map›Paper›PMID 40593205›Full record

ReviewResults and problems in cell differentiation2025

Histone and Non-histone Reversible Acetylation in Development, Aging, and Disease.

Sezgin Gunes, Neslihan Hekim, Sercan Ergun, Elzem Nisa Alkan, Cansu Can

Abstract readReview
PubMed Publisher
In one paragraph

Review in Results and problems in cell differentiation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sezgin GunesDepartment of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun, Türkiye. sgunes@omu.edu.tr.
Neslihan HekimDepartment of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun, Türkiye.
Sercan ErgunDepartment of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun, Türkiye.
Elzem Nisa AlkanDepartment of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun, Türkiye.
Cansu CanDepartment of Medical Biology, Medical Faculty, Ondokuz Mayis University, Samsun, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-translational modifications (PTM) involve chemical modifications of amino acid residues within histone and non-histone proteins and are chemically diverse. PTM plays a vital role in regulating the chromatin structure in the nucleus, thus gene regulation. Among the various PTM, reversible acetylation of histone non-histone proteins has fundamental functions in various cellular processes. In all organisms, histone acetylation of lysine residues is connected with transcription activation. Acetyltransferases and deacetylases are well-known enzymes in the acetylation of the histone and non-histone proteins. This chapter will review the latest progress in histone and non-histone reversible acetylation epigenetic alterations and mechanisms and summarize how they affect development, aging, and diseases.

Indexed as

AgingHistonesProtein Processing, Post-TranslationalAcetylationAnimalsEpigenesis, GeneticHumansHistones

Identifiers

PMID40593205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.