ArticleScientific reports2025
High GOLT1A expression induces poor prognosis in papillary thyroid carcinoma.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This study aims to investigate the clinical relevance of GOLT1A in papillary thyroid carcinoma (PTC) and evaluate its significance in prognosis of PTC. In this study, 527 data downloaded from the TCGA database and 280 data downloaded from the GTEx database were used for differential gene expression analysis. Univariate and multivariate statistical analyses were performed on the data of 499 PTC patients from the TCGA database and the data of 305 PTC patients subjected to fine-needle aspiration biopsy (FNAB) from the Department of General Surgery of the First Affiliated Hospital of Soochow University and the First Affiliated Hospital of Wenzhou Medical University. In the gene expression of 527 normal tissues and thyroid carcinoma tissues data from the TCGA database and 280 normal tissues from the GTEx database, the expression of GOLT1A was significantly higher in thyroid carcinoma tissues than in normal thyroid tissues (P < 0.001), validated by GEO databases (P < 0.001) and immunohistochemical (IHC) (P < 0.05). Univariate and multivariate analyses of 499 PTC patients and 309 FNAB PTC patients in the TCGA database showed that high expression of GOLT1A was closely related to the poor prognosis of PTC. Specifically, GOLT1A is associated with differentiation risk (P = 0.005), sex (P = 0.006), capsular invasion (P = 0.038) and lateral lymph node metastasis (P < 0.001). In summary, the expression of GOLT1A in thyroid carcinoma tissues was significantly higher than that in normal tissues, and high GOLT1A expression was probably related to the poor prognosis of PTC. GOLT1A is a promising prognostic genetic marker and pathogenic target of PTC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.