Evidence map›Paper›PMID 40593094›Full record

SynthesisScientific reports2025

Gastroesophageal disease risk and inhalational exposure a systematic review and meta-analysis.

Daniel Hyun Kim, Sanjiti Podury, Aida Fallah Zadeh, Tara Mahmoodi, Sophia Kwon, Gabriele Grunig, Mengling Liu, Anna Nolan

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Daniel Hyun KimDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA.
Sanjiti PoduryDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA.
Aida Fallah ZadehDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA.
Tara MahmoodiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA.
Sophia KwonDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA.
Gabriele GrunigDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA.
Mengling LiuDivision of Biostatistics, Department of Population Health, NYUGSoM, New York, NY, USA.
Anna NolanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University Grossman School of Medicine (NYUGSoM), New Bellevue, 16N Room 20 (Lab), 462 1st Avenue, New York, NY, 10016, USA. anna.nolan@med.nyu.edu.

Funding

Institutional Career DevelopmentKL2TR001446 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PILLINGER, MICHAEL · 2015 to 2025
$6.7M
SEMIPARAMETRIC METHODS FOR MODELING OF TIME-DEPENDENT ENVIRONMENTAL EXPOSURESR01ES032808 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIU, MENGLING · 2021 to 2025
$1.8M
CDC HHS U01-OH012069NCATS NIH HHS KL2 TR001446NHLBI NIH HHS L70 HL170444NIEHS NIH HHS R01 ES032808NIH HHS KL2TR001446NIH HHS R01ES032808NIOSH CDC HHS K01 OH012795NIOSH CDC HHS U01 OH012069
6 · The paper itself

Abstract

Environmental exposure-associated diseases, particularly in the context of rising air pollution and inhalant use, are an active area of research. Our group is dedicated to the study of exposure-related inflammation and its downstream adverse health effects. While many studies have focused on the impact of environmental exposures on respiratory sequelae, there is growing evidence of the involvement of other systems including gastrointestinal. This systematic review provides updates on the associations between inhalation exposures and the risk of upper gastrointestinal disease. Primary search identified N = 764 PubMed and N = 1,036 Web of Science studies, of which N = 111 met eligibility criteria. Our systematic review and meta-analysis showed significant associations between inhalational exposures (cigarette smoking, waterpipe smoking, and particulate matter) and upper gastrointestinal diseases. The pooled estimate of esophagitis was 1.32 (95% confidence interval [CI], 1.06-1.65; I

Indexed as

Gastroesophageal RefluxGastrointestinal DiseasesInhalation ExposureEsophageal NeoplasmsHumansParticulate MatterRisk FactorsParticulate MatterAerodigestive diseaseEnvironmental exposureMeta-analysisParticulate matterSmokingSystematic review

Identifiers

PMID40593094
PMCPMC12218983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.