ArticleScientific reports2025
An integrated widely targeted metabolomics and network pharmacology study of Persicaria runcinata var. Sinensis against arthritis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The present study aimed to investigate the material basis of Persicaria runcinata var. sinensis (Hemsl.) Bo Li using widely targeted metabolomics and network pharmacology techniques. Efforts were also made to establish a DNA barcode for P. runcinata var. sinensis. Widely targeted metabolomics technique of Ultra performance liquid chromatography-mass spectrometry(UPLC-MS/MS) was employed to detect and analyze the metabolites in P. runcinata var. sinensis. Network pharmacology was used to screen and analyze metabolites with high content and pharmacological effects. DNA extraction, Polymerase chain reaction(PCR) amplification, sequence alignment, and phylogenetic tree construction were performed to establish the DNA barcode. A total of 716 metabolites were detected in Miao ethnomedicine P. runcinata var. sinensis, with key targets, enriched functions, and pathways identified using network pharmacology. The DNA sequence for the ITS2 primer of P. runcinata var. sinensis was determined and a phylogenetic tree was generated. Metabolite enrichment in P. runcinata var. sinensis revealed potential therapeutic compounds for arthritis. The study's approach provided theoretical support for understanding the substance basis and therapeutic effects of P. runcinata var. sinensis. Additionally, the high homology level with various Polygonum species provided the foundation for molecular identification in ethnomedicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.