ArticleScientific reports2025
A comprehensive epidemiological analysis of breast cancer in the Eastern Province of Saudi Arabia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Article
- Article
- Breast Cancer Patterns in Saudi Arabia (2007-2022): A Nationwide Cancer Registry Surveillance Study.Journal of clinical medicine · 2026Article
- Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients.Scientific reports · 2026Article
- Exome-Wide Association Analysis Identifies Rare Germline Susceptibility Variants in Early-Onset Breast Cancer Among Saudi Women.International journal of molecular sciences · 2026Article
- Genomic and epigenomic diversity of breast cancer across Western and MENA populations: implications for precision oncology.Frontiers in oncology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is a leading health concern in Saudi Arabia, characterized by unique demographic and clinical profiles. This study analyzed breast cancer cases at King Fahad Specialist Hospital-Dammam (KFSH-D), focusing on age at diagnosis, disease stage, histological type, and hormonal receptor status. A retrospective cohort study included 5,954 breast cancer patients diagnosed between 2006 and 2022 from the KFSH-D database. Data were extracted via a Real-World Evidence Digital Platform adhering to international standards. Statistical analyses included descriptive statistics, Chi-square tests, t-tests, incidence and mortality rate calculations, survival analysis, and predictive modeling for future incidence trends. The cohort had a mean age at diagnosis of 49 years (SD = 12.0), with most patients aged 40-59 years. Over 99% were female and predominantly Saudi nationals. Approximately two-thirds presented with locally advanced disease, with invasive ductal carcinoma being the most common type (81%). Al Ahsa region accounted for 31% of referral cases. Hormonal receptor status showed 59% HER2-negative, 61% ER-positive, and 56% PR-positive. Predictive modeling forecasted an 80% increase in new cases by 2028, with incidence rates expected to double. This study highlights a younger median age at diagnosis and a high prevalence of late-stage disease. These findings underscore the urgent need for improved screening programs, targeted public health interventions, and better healthcare access in Saudi Arabia.
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