ArticleScientific reports2025
Evaluation of biological sex on endstage pathobiology and regenerative treatment of volumetric muscle loss.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Loss of ovarian hormones modulates sex-specific metabolic adaptations to volumetric muscle loss.American journal of physiology. Cell physiology · 2026Article
- Multifunctional scaffold based on TiMaterials today. Bio · 2026Article
- When rehabilitation is not enough, how targeting metabolism can overcome the limited plasticity of skeletal muscle after traumatic injury.Experimental physiology · 2026Review
- Novel assessment of postprandial metabolism reveals sex-specific metabolic flexibility and lipid remodeling following volumetric muscle loss.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Accumulation of lipids after acute direct and indirect traumatic injuries in male and female mice.BMC musculoskeletal disorders · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Volumetric muscle loss (VML) is a severe injury resulting in substantial skeletal muscle loss, leading to a complex pathology that culminates in suboptimal tissue repair and significant long-term functional deficits. This study employs a rodent model of VML to investigate the impact of biological sex on the injury pathobiology and its potential influence on the response to autologous minced muscle grafting (MMG) as a regenerative therapy. While no significant differences were observed between the end-stage male and female responses to VML, both male and female subjects appeared to benefit from MMG treatment. Females demonstrated improved neuromuscular function, while males exhibited reduced fibrosis at the site of injury. Additional differences in the wound healing response included distinct variations in myofiber characteristics, with females exhibiting a lower proportion of Type 2a fibers and elevated levels of myogenin. These findings suggest that regenerative therapies, such as MMG, may exhibit sex-specific benefits. Future studies will further explore sexual dimorphism in the acute response to injury to identify potential therapeutic targets that may yield greater therapeutic efficacy for each sex.
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Registered trials
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