Evidence map›Paper›PMID 40592928›Full record

ArticleScientific reports2025

Investigating the potential of oxidative stress-related gene as predictive markers in idiopathic pulmonary fibrosis.

Yuhao Wang, Zhao Zhang, Hongnan Zhang, Luyao Xu, Shuling Huang, Ying Wen, Zhiming Zhuang, Xiaoxin Li, Jinyi Lu, Xudong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuhao Wang *Guangdong Research Center of Occupational Hygiene, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510399, Guangdong, China.
Zhao Zhang *School of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Hongnan ZhangLonggui Street Community Health Service Center, Baiyun Distric, Guangzhou, 510445, Guangdong, China.
Luyao XuSchool of Public Health, Sun Yat-sen University, Guangzhou, 510275, Guangdong, China.
Shuling HuangSchool of Public Health, Guangzhou Medical University, Guangzhou, 511436, Guangdong, China.
Ying WenGuangzhou Women and Children's Medical Centre, Institute of Pediatrics, Guangzhou Medical University, Guangzhou, 510623, Guangdong, China.
Zhiming ZhuangSchool of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Xiaoxin LiSchool of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Jinyi LuSchool of Public Health, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Xudong LiGuangdong Research Center of Occupational Hygiene, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, 510399, Guangdong, China. lixd116@126.com.

Funding

Natural Science Foundation of Guangdong Province 2023A1515011329Natural Science Foundation of Guangdong Province 2025A1515012984Open Project of Anhui Province Key Laboratory of Occupational Health Grant No. 2024ZYJKC001Research Funds of Joint Research Center for Occupational Medicine and Health of IHM NO.OMH-2023-19
6 · The paper itself

Abstract

This study investigates genes linking oxidative stress to idiopathic pulmonary fibrosis (IPF) through multi-omics data integration. We collected oxidative stress-related genes from GeneCards and integrated data for gene expression (eQTLs), DNA methylation (mQTLs), and protein expression (pQTLs). Genome-wide association study (GWAS) data on IPF from Allen et al. served as the discovery set, with FinnGen R10 for validation. Summary data-based Mendelian randomization (SMR) and colocalization analyses assessed interactions and shared causal variants, followed by multi-omics integration with tissue-specific validation. SMR and colocalization screening identified 90 mQTLs, 15 eQTLs, and 2 pQTLs (KRT18 and FOXO1) linked to IPF in the discovery cohort. Twelve mQTLs were validated in the FinnGen cohort, with MUC1 showing strong SMR and colocalization evidence (eQTL). Multi-omics integration validated NDUFA9 (mQTL-eQTL) level and FOXO1 (mQTL-eQTL-pQTL). Our study identified key oxidative stress-related genes (i.e., FOXO1 and NDUFA9) in IPF pathogenesis, highlighting the need for further research to inform prevention and treatment.

Indexed as

Idiopathic Pulmonary FibrosisOxidative StressBiomarkersDatasets as TopicDNA MethylationElectron Transport Complex IForkhead Box Protein O1Gene Expression RegulationGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLungMendelian Randomization AnalysisMultiomicsPolymorphism, Single NucleotideBiomarkersElectron Transport Complex IForkhead Box Protein O1FOXO1 protein, humanNDUFA9 protein, humanColocalization analysisIdiopathic pulmonary fibrosisMendelian randomization analysisMulti-omicsOxidative stress

Identifiers

PMID40592928
PMCPMC12218310

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.