Evidence map›Paper›PMID 40592920›Full record

ArticleScientific reports2025

Prognostic model of lung adenocarcinoma from the perspective of cancer-associated fibroblasts using single-cell and bulk RNA-sequencing.

Jiarui Zhao, Chuanqing Jing, Rui Fan, Wei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiarui ZhaoCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Chuanqing JingCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Rui FanCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Wei ZhangCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China. 2018128006@sdutcm.edu.cn.

Funding

The National Natural Science Foundation of China. 81874442
6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) play important roles in the progression of lung adenocarcinoma (LUAD). We examined CAF subgroups via gene ontology, pseudo-time, and cell communication analyses and explored their prognostic value in LUAD using a digital cytometric machine learning algorithm. Next, we got a prognostic model based on CAF subgroups. We also screened potential therapeutic target genes in LUAD and experimentally validated the proliferation, migration, and invasion phenotypes related to these target genes. We identified myofibroblastic CAFs (MyCAFs) and Immune-related CAFs (ImmCAFs) as the major CAF subgroups in LUAD. Further, our inverse convolution algorithm showed that MyCAFs have prognostic potential in LUAD, and via LASSO-COX model regression, we obtained a MyCAFs-related prognostic model. We found POSTN as a potential therapeutic target in LUAD. These findings serve as a foundation for further studies on CAFs.

Indexed as

Adenocarcinoma of LungCancer-Associated FibroblastsLung NeoplasmsBiomarkers, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMachine LearningPrognosisSequence Analysis, RNASingle-Cell AnalysisBiomarkers, TumorCancer-associated fibroblastsLung adenocarcinomaMachine learningSingle-cell and bulk RNA-sequencing

Identifiers

PMID40592920
PMCPMC12216014

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.