Methylations with methanol via bioinspired catalytic C-O bond cleavage.

Qing Huang, Yao Xiang, Yaqi Wu, Yuzhu Zheng, Rong-Zhen Liao, Youwei Xie

Abstract read

In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qing HuangHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China.

Yao XiangHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China.

Yaqi WuHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China.

Yuzhu ZhengHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China.

Rong-Zhen LiaoHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China. rongzhen@hust.edu.cn.ORCID http://orcid.org/0000-0002-8989-6928

Youwei XieHubei Key Laboratory of Bioinorganic Chemistry and Materia Medica; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China. xieyw@hust.edu.cn.ORCID http://orcid.org/0000-0003-3831-4059

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21801084，22171095

6 · The paper itself

Abstract

Nature has a delicate system for catalysis due to optimization through evolution, which often displays unparalleled efficiency and selectivity. "Learning from nature" is a popular and effective approach in designing alternative reactions and catalysts when traditional strategies fail. Here, we demonstrate that it can be highly rewarding to consider nature's repertoire of catalysis during the effort to facilitate the challenging heterolytic C-O bond cleavage of methanol (MeOH). Inspired by MeOH metabolism by methyltransferase complex in certain methanogenic microorganisms that contain a Brønsted acid cluster flanked by a Zinc moiety, we successfully identify the combination of an easily available Brønsted acid and Zn(OTf)

Identifiers

PMID40592918

DOI10.1038/s41467-025-61200-7

PMCPMC12219698

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.