Evidence map›Paper›PMID 40592905›Full record

ArticleScientific reports2025

Global estimates of vaccine-associated narcolepsy from 1967 to 2023.

Yi Deun Jeong, Hyesu Jo, Yesol Yim, Sooji Lee, Jaeyu Park, Jinseok Lee, Jiseung Kang, Louis Jacob, Lee Smith, Masoud Rahmati and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yi Deun Jeong *Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
Hyesu JoCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. prejhs@naver.com.
Yesol Yim *Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
Sooji LeeDepartment of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
Jaeyu ParkCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
Jinseok LeeDepartment of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.
Jiseung KangDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Louis JacobResearch and Development Unit, Parc Sanitari Sant Joan de Déu, Barcelona, Spain.
Lee SmithCentre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
Masoud RahmatiResearch Centre on Health Services and Quality of Life, Assistance Publique-Hôpitaux de Marseille, Aix Marseille University, Marseille, France.
Guillermo F López SánchezDivision of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain.
Hayeon LeeCenter for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
Dong Keon YonDepartment of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. yonkkang@gmail.com.

Funding

National Research Foundation of Korea RS-2023-00248157
6 · The paper itself

Abstract

Regional evidence on the signal detection between narcolepsy and vaccines is scarcely available and insufficiently understood, thus impeding a comprehensive understanding of this relationship on a global scale. Therefore, this study aimed to evaluate the global estimates of vaccine-associated narcolepsy, discern its association with specific vaccines, and thereby contribute to the advancement of more efficient vaccination protocols. This study utilized data from the international pharmacovigilance database concerning vaccine-associated narcolepsy from 1967 to 2023. Global reporting counts, reported odds ratios (ROR), and information components (IC) were analyzed to identify the signal detection between the 16 vaccines and the occurrence of vaccine-associated narcolepsy across 140 countries. We identified 2,183 reports (male, n = 870 [39.85%]) of vaccine-associated narcolepsy from 5,291 reports of narcolepsy. Vaccine-associated narcolepsy has been reported since 2009. The highest disproportionality signals for narcolepsy were observed with influenza vaccines (ROR, 156.53 [95% CI, 147.62-165.97]; IC, 6.72 [IC

Indexed as

NarcolepsyVaccinesAdolescentAdultAgedChildChild, PreschoolFemaleGlobal HealthHumansInfantMaleMiddle AgedPharmacovigilanceVaccinationYoung AdultVaccinesGlobalNarcolepsyVaccineVaccine-associated narcolepsy

Identifiers

PMID40592905
PMCPMC12215190

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.