ArticleNPJ science of food2025
Dynamic shifts in metabolic demand during myogenic progression in porcine skeletal muscle stem cells.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Food-grade utilization of bovine slaughterhouse by-products for developing cost-effective media supplements in cultivated meat applications.Food science of animal resources · 2026Review
- TEAD4 Promotes Myogenic Differentiation of Porcine Skeletal Muscle Satellite Cells.Animals : an open access journal from MDPI · 2026Article
- Critical regulatory pathways for the development of sheep myoblasts and the enhancement of cultured meat quality.Food chemistry: X · 2026Article
- Advances in porcine stem cell research and their applications in agriculture.Frontiers in cell and developmental biology · 2026Review
- IGF2 regulates proliferation, differentiation, and mitochondrial bioenergetics in human satellite cells.Biology direct · 2025Article
- Survey on the Global Technological Status for Forecasting the Industrialization Timeline of Cultured Meat.Foods (Basel, Switzerland) · 2025Review
- Glutamine Promotes Myogenesis in Myoblasts Through Glutaminolysis-Mediated Histone H3 Acetylation That Enhances Myogenin Transcription.Nutrients · 2025Article
- Peroxisome Proliferator-Activated Receptor Delta Regulates Myogenic Differentiation via Lipid Droplet-Associated Metabolic Remodeling and p38 MAPK Signaling.Animal science journal = Nihon chikusan GakkaihoArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Optimizing the metabolic environment during porcine skeletal muscle stem cells (PSCs) proliferation and differentiation is essential for efficient muscle cell cultivation. This study investigated metabolic shifts during myogenic progression using cells at P1, P3, D1, and D2 for characterization and metabolomic analysis. Cell number increased until P3, and myotubes formed by D2 but detached by D3 in 2D culture. Gene and protein expression analyses confirmed myogenic progression, including increased MYOD and MHC expression. Metabolomic profiling identified 94 intracellular metabolites, with 24 and 17 differentially abundant metabolites (DAMs) in proliferation and differentiation, respectively. Pathway analysis showed that energy production via amino acid metabolism was key to progression. Notably, PSCs relied on glycolysis during proliferation and shifted to mitochondrial oxidative phosphorylation during differentiation. These results highlight stage-specific metabolic reprogramming and provide insights for optimizing culture conditions, offering foundational knowledge to improve the efficiency and quality of cultured meat production.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.