ArticleNPJ science of food2025
Aflatoxin B1 and Eimeria ovinoidalis impairs meat quality of sheep by regulating the HIF-1ɑ/HK2/glycolysis axis.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Gut microbiota and meat quality in ruminants: a review of mechanisms and microbiota-targeted interventions.Food science of animal resources · 2026Review
- Comparative analysis of the extreme meat color transcriptome reveals key regulatory genes and identifies potential SNPs in Leiqiong cattle.BMC genomics · 2026Article
- Cyanidin-3-O-galactoside improves meat quality, flavor and health attributes in small-tailed han lambs.NPJ science of food · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
Mutton consumption is increasing due to its abundant nutritional elements and flavorful taste. However, sheep breeding is inevitably influenced by various factors, including feed mycotoxin contamination and parasitic infection. In this study, we investigated the effect of aflatoxin B1 (AFB1) and Eimeria ovinoidalis (EO) on sheep meat quality following a two-week treatment. The results showed that oxidative stress triggered by EO or AFB1 in feed could cause significant changes in meat quality. Metabolomics and transcriptomics further revealed that the alteration in mutton quality is closely associated with glycolysis mediated by the hypoxia inducible factor-1α (HIF-1α) pathway. Interestingly, the glycolytic enzyme hexokinase 2 (HK2), a downstream gene of the HIF-1α pathway, exhibits a strong affinity for AFB1 and its metabolites, as revealed by molecular docking analysis, which is associated with a change in mutton quality-related indices. These findings provide novel insights that Eimeria or/and AFB1 compromise mutton quality by disrupting the HIF-1α/HK2/glycolysis axis.
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Registered trials
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