Evidence map›Paper›PMID 40592812›Full record

ArticleNature communications2025

Unsupervised learning of temporal regularities in visual cortical populations.

Sorin Pojoga, Ariana Andrei, Valentin Dragoi

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sorin PojogaDepartment of Neurobiology and Anatomy, McGovern Medical School, University of Texas, Houston, TX, USA.
Ariana AndreiDepartment of Neurobiology and Anatomy, McGovern Medical School, University of Texas, Houston, TX, USA.
Valentin DragoiCenter for Neural Systems Restoration, Houston Methodist Research Institute, Dept. of Neurosurgery, Houston, TX, USA. vdragoi@houstonmethodist.org.ORCID http://orcid.org/0000-0002-9526-0926

Funding

Cortical encoding of unconscious visual information and its impact on behaviorR01EY031588 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DRAGOI, VALENTIN · 2020 to 2024
$1.9M
NEI NIH HHS R01 EY031588U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R01EY031588
6 · The paper itself

Abstract

The brain's ability to extract temporal information from dynamic stimuli in the environment is essential for everyday behavior. To extract temporal statistical regularities, neural circuits must possess the ability to measure, produce, and anticipate sensory events. Here we report that when neural populations in macaque primary visual cortex are triggered to exhibit a periodic response to a repetitive sequence of optogenetic laser flashes, they learn to accurately reproduce the temporal sequence even when light stimulation is turned off. Despite the fact that individual cells had a poor capacity to extract temporal information, the population of neurons reproduced the periodic sequence in a temporally precise manner. The same neural population could learn different frequencies of external stimulation, and the ability to extract temporal information was found in all cortical layers. These results demonstrate a remarkable ability of sensory cortical populations to extract and reproduce complex temporal structure from unsupervised external stimulation even when stimuli are perceptually irrelevant.

Indexed as

LearningNeuronsPrimary Visual CortexVisual CortexAnimalsMacaca mulattaMaleOptogeneticsPhotic StimulationVisual Perception

Identifiers

PMID40592812
PMCPMC12216384

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.