Evidence map›Paper›PMID 40592527›Full record

SynthesisAJNR. American journal of neuroradiology2025

Hydrogel Coils versus Bare Platinum Coils for the Treatment of Ruptured and Unruptured Aneurysms: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Jonathan Cortese, Sherief Ghozy, Armin Zarrintan, Delal Bektas, Omar M Al-Janabi, Onam Verma, Esref Alperen Bayraktar, Waleed Brinjikji, Ramanathan Kadirvel, David F Kallmes

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan CorteseFrom the Department of Radiology (J.C., S.G., A.Z., E.A.B., W.B., D.F.K.), Mayo Clinic, Rochester, Minnesota cortese.jonathan@mayo.edu.ORCID https://orcid.org/0000-0002-1616-9113
Sherief GhozyFrom the Department of Radiology (J.C., S.G., A.Z., E.A.B., W.B., D.F.K.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0001-5629-3023
Armin ZarrintanFrom the Department of Radiology (J.C., S.G., A.Z., E.A.B., W.B., D.F.K.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-1217-648X
Delal BektasDepartment of Neurologic Surgery (S.G., D.B., R.K.), Mayo Clinic, Rochester, Minnesota.
Omar M Al-JanabiDepartment of Neurology (O.M.A.-J.), Banner-University Medical Center, Tucson, Arizona.
Onam VermaInstitute of Medical Education and Research (PGIMER) (O.V.), Chandigarh, India.
Esref Alperen BayraktarFrom the Department of Radiology (J.C., S.G., A.Z., E.A.B., W.B., D.F.K.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-8245-2689
Waleed BrinjikjiFrom the Department of Radiology (J.C., S.G., A.Z., E.A.B., W.B., D.F.K.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0001-5271-5524
Ramanathan KadirvelDepartment of Neurologic Surgery (S.G., D.B., R.K.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-6786-9953
David F KallmesFrom the Department of Radiology (J.C., S.G., A.Z., E.A.B., W.B., D.F.K.), Mayo Clinic, Rochester, Minnesota.ORCID https://orcid.org/0000-0002-8495-0040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWhether hydrogel coils (HGCs) can reduce intracranial aneurysm recurrences when compared with bare platinum coils (BPCs) remains a disputed subject. Thus, we sought to perform a systematic review and meta-analysis to evaluate the efficacy of hydrogel coils in the context of intracranial aneurysm treatment. MATERIALS AND

methodsFollowing PRISMA 2020 guidelines, we systematically reviewed PubMed, Scopus, Embase, and Web of Science for randomized controlled trials (RCTs) comparing HGC to BPC. Outcomes of interest were: end of procedure and last follow-up occlusion rates, including complete occlusion and major recurrence, complication rates, morbidity, and mortality. Risk ratios (RRs) and 95% CIs were calculated.

resultsThe study selection: 5 RCTs, including 2126 patients (HGC

conclusionsOur meta-analysis of RCTs suggests that the use of HGC in the endovascular treatment of intracranial aneurysms results in significantly lower rates of recurrence compared with BPC, with both coil types showing similar initial occlusion rates and safety profiles.

Indexed as

Aneurysm, RupturedEmbolization, TherapeuticHydrogelsIntracranial AneurysmPlatinumHumansRandomized Controlled Trials as TopicTreatment OutcomeHydrogelsPlatinum

Identifiers

PMID40592527
PMCPMC12453439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.